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Exploring the neuroprotective potential of immunosuppressants in Parkinson's disease.
Parkinsonism Relat Disord
January 2025
Department of Neurology, Washington University School of Medicine in St. Louis, 660 S Euclid Ave, St. Louis, MO, 63110, USA. Electronic address:
Introduction: Neuroprotective therapy to slow Parkinson's disease (PD) progression is a critical unmet need. Neuroinflammation likely represents an important pathophysiologic mechanism for disease progression. Medications that target this inflammation, such as immunosuppressants, represent potential disease-modifying therapies for PD.
View Article and Find Full Text PDFAutoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and autoantibodies. While such autoreactivities are believed to be generated during germinal centre reactions, the roles of earlier immune checkpoints in autoantigen-specific B cell tolerance are poorly understood.
View Article and Find Full Text PDFExtreme migratory connectivity and apparent mirroring of non-breeding grounds conditions in a severely declining breeding population of an Afro-Palearctic migratory bird.
Sci Rep
January 2025
British Trust for Ornithology, The Nunnery, Thetford, Norfolk, IP24 2PU, UK.
Understanding the distribution of breeding populations of migratory animals in the non-breeding period (migratory connectivity) is important for understanding their response to environmental change. High connectivity (low non-breeding population dispersion) may lower resilience to climate change and increase vulnerability to habitat loss within their range. Very high levels of connectivity are reportedly rare, but this conclusion may be limited by methodology.
View Article and Find Full Text PDFDen Use Patterns of Endangered San Joaquin Kit Foxes in Urban Environments May Facilitate Disease Transmission.
Animals (Basel)
January 2025
Endangered Species Recovery Program, California State University-Stanislaus, 1 University Circle, Turlock, CA 95382, USA.
A robust population of endangered San Joaquin kit foxes (; SJKFs) occurs in the city of Bakersfield, CA. In 2013, sarcoptic mange was detected and significantly reduced SJKF abundance. Dens may be a mode of mange mite transmission.
View Article and Find Full Text PDFCropland associated with risk of Parkinson's disease in the northern Great Plains.
Parkinsonism Relat Disord
January 2025
Department of Neurology, Barrow Neurological Institute, 240 W Thomas Rd, Phoenix, AZ, 85013, USA; Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, Missouri, 63110, USA; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South Africa. Electronic address:
Introduction: We sought to identify regional associations between cropland density and crop types and PD in the U.S.
Methods: We conducted a population-based study of 21,639,190 Medicare beneficiaries, 89,790 with incident PD in 2009.
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