After spontaneous recovery from infestation by Strongyloides ratti, reinfestation by a new generation of adult parasites is not possible if the primary infestation was by 5,000 or 10,000 larvae administered in one or more contacts and if the secondary infestation takes place 3 weeks after. Reinfestation becomes possible again 51 days after recovery from a primary infestation by 15,000 larvae. However although the larvae do not reach the adult stage, they do begin their migration and cause hypersecretion of gluco-cortico-steroids. There is thus a contrast between the ease with which the organism rapidly and lastingly prevents the transformation of larvae into adults and the difficulty in neutralising the larvae and preventing them from triggering a stress.
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Parasit Vectors
December 2024
Department of Evolution, Ecology and Behaviour, University of Liverpool, Liverpool, L69 7ZB, UK.
Background: Strongyloides nematodes are livestock parasites, and Strongyloides papillosus infecting ruminant livestock can cause disease. Recent genomic analysis of several Strongyloides species is now facilitating population genomic analyses of natural Strongyloides infections, for example finding that Strongyloides ratti in wild UK rats exists as an assemblage of long-lived, asexual lineages.
Methods: Here we have initiated an investigation into the population genomics of S.
PLoS Negl Trop Dis
December 2024
Department of Neurobiology and Biophysics, University of Washington, Seattle, Washington, United States of America.
Soil-transmitted parasitic nematodes infect over 1 billion people worldwide and are a common source of neglected disease. Strongyloides stercoralis is a potentially fatal skin-penetrating human parasite that is endemic to tropical and subtropical regions around the world. The complex life cycle of Strongyloides species is unique among human-parasitic nematodes in that it includes a single free-living generation featuring soil-dwelling, bacterivorous adults whose progeny all develop into infective larvae.
View Article and Find Full Text PDFPLoS One
December 2024
Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Detection of Strogyloides-specific IgG antibodies in urine and serum has been used in diagnostic and epidemiological studies on strongyloidiasis. However, the usefulness of these assays in assessing responses to anthelmintic treatment is unclear. Thus, we evaluated the diagnostic performance and temporal profiles of Strongyloides-specific IgG antibodies in a cohort of participants at baseline and post-treatment.
View Article and Find Full Text PDFMucosal Immunol
November 2024
Section Interface, Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany; Department for Biology, University Hamburg, 20148, Hamburg, Germany. Electronic address:
Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S.
View Article and Find Full Text PDFPLoS Negl Trop Dis
October 2024
Instituto de Ganadería de Montaña (CSIC-Universidad de León), Grulleros, León, Spain.
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