Gardner's syndrome is a dominant autosomal non sex-linked hereditary condition resulting from lesions of all three primary germ layers : ectoderm, entoderm and mesoderm. It therefore includes a variety of symptoms which concern E.N.T. specialists, dermatologists, maxillo-facial surgeons and gastroenterologists, although the present tendency is to recognize the existence of partial or dissociated Gardner's syndromes. The finding of an isolated symptom of the Gardner's series should lead to a systematic search for polyposis of the large bowel, as the latter carries a short- or long-term risk of malignant degeneration which has considerable bearing on prognosis.
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