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Qiangji Decoction mitigates neuronal damage, synaptic and mitochondrial dysfunction in SAMP8 mice through the regulation of ROCK2/Drp1-mediated mitochondrial dynamics.
J Ethnopharmacol
January 2025
Health Medical Center, Hubei Minzu University, Enshi, Hubei, 445000, PR China; Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Disease, Hubei Minzu University, Enshi, Hubei, 445000, PR China. Electronic address:
Ethnopharmacological Relevance: Qiangji Decoction (QJD), a Chinese medicine, is widely used in Traditional Chinese Medicine to treat amnesia and Alzheimer's disease (AD), showing significant anti-AD effects. However, the precise mechanisms behind these effects are not well understood and require more research.
Aim Of The Study: This study aims to elucidate the mechanisms by which QJD ameliorates neuronal damage, synaptic dysfunction, and mitochondrial impairment in AD through the regulation of ROCK2/Drp1-mediated mitochondrial dynamics.
Syringic acid protective role: Combatting oxidative stress induced by UVB radiation in L-929 fibroblasts.
J Photochem Photobiol B
January 2025
Post-Graduate Program in Pharmaceutical Sciences, State University of Maringá, Maringá, Paraná, Brazil. Electronic address:
Neglecting proper skin care and repeated exposure to ultraviolet (UV) radiation can have serious consequences, including skin burns, photoaging and even the development of skin cancer. UV radiation-induced damage is mediated by highly unstable and reactive molecules, named reactive oxygen species (ROS). To counteract ROS, the skin has an endogenous antioxidant system.
View Article and Find Full Text PDFWhy has the 'miracidium' of Notocotylidae (Trematoda: Digenea) lost all stage-specific traits?
Parasitol Res
January 2025
Department of Invertebrate Zoology, Saint Petersburg University, Universitetskaya emb., 7/9, Saint Petersburg, 199034, Russia.
Digeneans of the family Notocotylidae differ from other digeneans in their peculiar eggs. The eggs feature a pair of long filaments extending from their poles, and their contents differ significantly from what we expect to observe in the eggs of digeneans. Instead of a ciliated miracidium larva, the notocotylid egg contains a tiny few-celled mother sporocyst.
View Article and Find Full Text PDFA Statistically-Robust Model of the Axomyelin Unit under Normal Physiologic Conditions with Application to Disease States.
ASN Neuro
January 2025
Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, USA.
Despite tremendous progress in characterizing the myriad cellular structures in the nervous system, a full appreciation of the interdependent and intricate interactions between these structures is as yet unfulfilled. Indeed, few more so than the interaction between the myelin internode and its ensheathed axon. More than a half-century after the ultrastructural characterization of this axomyelin unit, we lack a reliable understanding of the physiological properties, the significance and consequence of pathobiological processes, and the means to gauge success or failure of interventions designed to mitigate disease.
View Article and Find Full Text PDFCryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting.
Nucleic Acids Res
January 2025
Department of Physiology and Biophysics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, United States.
The Rep68 protein from Adeno-Associated Virus (AAV) is a multifunctional SF3 helicase that performs most of the DNA transactions necessary for the viral life cycle. During AAV DNA replication, Rep68 assembles at the origin of replication, catalyzing the DNA melting and nicking reactions during the hairpin rolling replication process to complete the second-strand synthesis of the AAV genome. We report the cryo-electron microscopy structures of Rep68 bound to the adeno-associated virus integration site 1 in different nucleotide-bound states.
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