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Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study.
J Neuroinflammation
September 2024
Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China.
Article Synopsis
- Early severe cerebral edema and chronic hydrocephalus significantly worsen the prognosis for patients with subarachnoid hemorrhage (SAH), prompting investigators to explore the role of inflammatory cytokines and coagulation factors in these conditions.
- A study involving 72 SAH patients categorized them by severity of cerebral edema and subsequent development of hydrocephalus, measuring levels of various inflammatory and coagulation factors in cerebrospinal fluid (CSF) shortly after SAH.
- Findings revealed that certain coagulation factors and inflammatory cytokines were strongly linked to both severe cerebral edema and chronic hydrocephalus, and a mouse model suggested that treatment with tissue plasminogen activator could help reduce inflammation and related brain swelling.
Sparse Group Penalties for bi-level variable selection.
Biom J
June 2024
Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Many data sets exhibit a natural group structure due to contextual similarities or high correlations of variables, such as lipid markers that are interrelated based on biochemical principles. Knowledge of such groupings can be used through bi-level selection methods to identify relevant feature groups and highlight their predictive members. One of the best known approaches of this kind combines the classical Least Absolute Shrinkage and Selection Operator (LASSO) with the Group LASSO, resulting in the Sparse Group LASSO.
View Article and Find Full Text PDFRole of Perturbated Hemostasis in MASLD and Its Correlation with Adipokines.
Life (Basel)
January 2024
Mediterranean Foundation "GB Morgagni", 95125 Catania, Italy.
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, making it one of the most prevalent chronic liver disorders. MASLD encompasses a range of liver pathologies, from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) with inflammation, hepatocyte damage, and fibrosis. Interestingly, the liver exhibits close intercommunication with fatty tissue.
View Article and Find Full Text PDFTrends among platelet function, arterial calcium, and vascular function measures.
Platelets
December 2023
National Heart, Lung and Blood Institute's the Framingham Heart Study, Boston University and National Heart, Framingham, MA, USA.
Article Synopsis
- The study examines the relationship between arterial tonometry, platelet function, and vascular calcification in assessing cardiovascular disease (CVD) risk among 3,429 participants from the Framingham Heart Study, highlighting a potential link between these variables.* -
- Findings suggest that higher levels of arterial calcium are associated with increased platelet reactivity, while larger aortic diameters correlate with lower platelet reactivity, indicating that vascular structure may influence platelet behavior.* -
- The analysis also indicates that various trends emerged regarding arterial characteristics and platelet function, although the results did not meet strict significance thresholds, suggesting a complex interplay between vascular health and platelet activation in the context of CVD.*
A conceptual framework for clinical and translational virtual community engagement research.
J Clin Transl Sci
October 2022
Institute for Healthcare Policy & Innovation, University of Michigan, Ann Arbor, MI, USA.
Introduction: The COVID-19 pandemic accelerated a trend for clinical and translational community-engaged research in adapting to an increasingly virtual landscape. This requires a framework for engagement distinct from in-person research and program activities. We reflect on four case studies of community engagement activities that inform a conceptual framework to better integrate the virtual format into community-engaged research reflecting key tenets of health equity and antiracist praxis.
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