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Size distribution of barrel-stave aggregates of membrane peptides: influence of the bilayer lateral pressure profile.
Biophys J
May 2002
Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA.
Some membrane peptides, such as Alamethicin, form barrel-stave aggregates with a broad probability distribution of size (number of peptides in the aggregate). This distribution has been shown to depend on the characteristics of the lipid bilayer. A mechanism for this influence is suggested, in analogy to earlier work on the effects of changes in bilayer composition on conformational equilibria in membrane proteins, that is based on coupling of shifts in the distribution of lateral pressures in the bilayer to depth-dependent changes in the lateral excluded area that accompanies the formation of an aggregate.
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