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Blood Trihalomethanes and Human Cancer: A Systematic Review and Meta-Analysis.
Toxics
January 2025
School of Public Health, MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical College, Soochow University, Suzhou 215123, China.
The control of waterborne diseases through water disinfection is a significant advancement in public health. However, the disinfection process generates disinfection by-products (DBPs), including trihalomethanes (THMs), which are considered to influence the occurrence of cancer. This analysis aims to quantitatively evaluate the relationship between blood concentrations of THMs and cancer.
View Article and Find Full Text PDFThe Role of Prenatal Exposure to Lead and Manganese in Child Cognitive Neurodevelopment at 18 Months: The Results of the Italian PHIME Cohort.
Toxics
January 2025
Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.
Prenatal lead (Pb) and manganese (Mn) exposure can impair neurodevelopment, targeting the central nervous system. This study investigated the effects of prenatal exposure to Pb and Mn on neurodevelopment in children at 18 months of age, using data from 607 Italian mother-child pairs enrolled in the Northern Adriatic Cohort II (NAC-II). All children born at term (≥37 weeks) were assessed with the Bayley Scales of Infant and Toddler Development, third edition.
View Article and Find Full Text PDFBotulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47.
Nat Struct Mol Biol
January 2025
Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Botulinum neurotoxins (BoNTs) rank among the most potent toxins and many of them are produced by bacteria carrying the orfX gene cluster that also encodes four nontoxic proteins (OrfX1, OrfX2, OrfX3 and P47). The orfX gene cluster is also found in the genomes of many non-BoNT-producing bacteria, often alongside genes encoding oral insecticidal toxins. However, the functions of these OrfXs and P47 remain elusive.
View Article and Find Full Text PDF3'-deoxytubercidin: A potent therapeutic candidate for the treatment of Surra and Dourine.
Int J Parasitol Drugs Drug Resist
January 2025
Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, 2610, Wilrijk, Belgium. Electronic address:
Surra and Dourine are widespread diseases caused by two protozoan parasites Trypanosoma brucei evansi and Trypanosoma brucei equiperdum, respectively. A wide range of animals including camels, horses, cattle and buffaloes are susceptible to infection. These diseases pose a significant socio-economic burden, primarily due to the limited therapeutic options and the complications associated with toxicity and drug resistance, making disease management particularly challenging.
View Article and Find Full Text PDFMelamine and cyanuric acid in milk and their quantities, analytical methods and exposure risk: A systematic review and meta-analysis.
J Food Prot
January 2025
Department of Environmental Health Engineering, Division of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Melamine, as a toxic compound, needs to be controlled in food, especially in dairy products. In this systematic study, quantities of melamine and cyanuric acid in various types of milk were investigated. A comprehensive database search was performed using the keywords pasteurized milk, milk, sterilized milk, melamine and cyanuric acid without time limitation.
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