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Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults.
J Int Med Res
December 2024
Department of Nephrology, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Objective: To explore the relationship between leukocyte count and renal function in patients with lupus nephritis (LN).
Methods: We performed a retrospective cross-sectional study of 100 patients with LN admitted to the Department of Nephrology between 1 January 2015 and 30 December 2023. Based on tertile of leukocyte count, they were allocated to Low, Medium, or High groups.
ELF1 serves as a potential biomarker for the disease activity and renal involvement in systemic lupus erythematosus.
Sci Rep
November 2024
Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230032, Anhui, China.
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, yet its underlying mechanisms remain unclear, and precise biomarkers are lacking. In this study, we employed Mendelian randomization and HEIDI tools to comprehensively analyze large-scale Genome-Wide Association Study (GWAS) and expression Quantitative Trait Loci (eQTL) data, leading to the identification of seven novel potential functional genes associated with SLE, including BLK, ELF1, STIM1, B3GALT6, APOLD1, INPP5B, and FHL3. Subsequent investigations revealed a significant downregulation of ELF1 gene expression in CD4 T cells of SLE patients compared to healthy controls.
View Article and Find Full Text PDFImmunogenicity risk assessment of empty capsids present in adeno-associated viral vectors using predictive innate immune responses.
J Pharm Sci
December 2024
Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA. Electronic address:
Immunogenicity of gene therapy and the impacts on safety and efficacy are of increasing interest in the pharmaceutical industry. Unique structural aspects of gene therapy delivery vectors, such as adeno-associated viral (AAV) vectors, are expected to activate the innate immune system. The risk of innate immune activation is critical to understand due to the potential impacts on safety and on subsequent adaptive immune responses.
View Article and Find Full Text PDFUtility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH).
Semin Arthritis Rheum
December 2024
Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 695, Rochester, NY 14642, United States. Electronic address:
Background: Activation of the complement cascade is thought to play a role in scleroderma vasculopathy. We previously showed that complement factor D was elevated in patients with limited cutaneous SSc and pulmonary arterial hypertension (PAH). In this study, we sought to assess multiple relevant components of the complement cascade to determine if they are altered in SSc-PAH, as well as their potential utility as biomarkers of disease severity and progression.
View Article and Find Full Text PDFLow pulse pressure and high serum complement C1q are risk factors for hemodialysis headache: A case-control study.
Headache
March 2024
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Background And Objective: Hemodialysis headache (HDH) is a common complication of dialysis that negatively affects the patient's quality of life. The etiology and triggering factors of HDH are not fully understood. This study aims to assess the prevalence and characteristics of HDH among patients undergoing hemodialysis across multiple centers in China.
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