Prospidin--N,N3-di(beta-chloroethyl)-N1,N2-dispirotripiperazinium - is a broad-spectrum antineoplastic drug with low toxicity. Experiments on albino rats with transplanted sarcoma M-1 were made to study the distribution and kinetics of 14C-prospidin labeled in the dispirotripiperazinium part of the molecule. On being given intravenously the drug accumulated for 15 minutes. The maximum value of the differential accumulation ratio (CAR) amounted to 3.34 (kidneys) and 0.16 (thymus). The content of the label in organs and tissues was related both to its presence in the blood and to the penetration into the cell structures. The magnitude of the integral indicator in the kidneys, liver, small intestine, bone marrow, lungs and tumor was considerably higher than in other organs. The accumulation of 14C-prospidin mainly by the lung tissue, bronchi, throat and bone marrow enables a correlation to be elucidated between the accumulation and antineoplastic action in the organs under consideration. The presence of the label in different fragments of the 14C-prospidin molecule (14C-dispirotripiperazinium and 14C-hydroxypropyl grouping) made it possible to establish that the DAR for the former label in organs and tissues 3--6 hours after the drug administration was 2--6 times greater than for the latter. As judged from the integral content of the label, prospidin had begun metabolizing and its biological activity decreased by the time indicated.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
High-throughput and sustainable B vitamins analysis in nutritional supplements, vegetables, and fruits via 2D carbon microfiber fractionation system coupled with mass spectrometry.
Talanta
January 2025
College of Pharmacy, Yanbian University, Park Road 977, Yanji, 133002, Jilin Province, PR China; Department of Chemistry, Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University, Park Road 977, Yanji, 133002, Jilin Province, PR China. Electronic address:
B vitamins are essential for energy metabolism, nervous health, blood production, and the immune system. Their quantification in nutritional supplements and food is mandatory to manage a correct daily intake and dosage. In this study, a fast and sustainable method for the analysis of 8 B vitamins (VB, VB, VB, nicotinamide, VB, VB, VB, VB) in real samples using a 2D-carbon microfiber fractionation system combined with a triple quadrupole mass spectrometer (2DμCFs-QqQ-MS/MS) is presented.
View Article and Find Full Text PDFMorphological and Chemical Changes in the Hemolymph of the Wax Moth Infected by the Entomopathogenic Fungus .
Pathogens
January 2025
Laboratory of Analysis of Natural Compounds, Department of Environmental Analysis, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
Hemolymph enables communication between organs in insects and ensures necessary coordination and homeostasis. Its composition can provide important information about the physiological state of an insect and can have diagnostic significance, which might be particularly important in the case of harmful insects subjected to biological control. Linnaeus 1758 (Lepidoptera: Pyralidae) is a global pest to honey bee colonies.
View Article and Find Full Text PDFEvaluating Different Supplements on the Growth Performance and Bioconversion Efficiency of Kitchen Waste by Black Soldier Fly Larvae.
Insects
December 2024
College of Agriculture and Biology, Shandong Province Engineering Research Center of Black Soldier Fly Breeding and Organic Waste Conversion, Liaocheng University, Liaocheng 252000, China.
Black soldier fly larvae (BSFL) convert kitchen waste into high-quality insect feed. However, the optimal amount of auxiliary materials needed to improve the physical and chemical properties of kitchen waste and enhance BSFL bioconversion efficiency remains unresolved. In this study, maize stover and BSFL frass were added to kitchen waste (in groups G2 and G3, respectively) to explore their effects on the growth performance and bioconversion efficiency of BSFL.
View Article and Find Full Text PDFDiverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment.
Int J Mol Sci
January 2025
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Alzheimer's disease (AD) pathogenesis is correlated with the membrane content of various lipid species, including cholesterol, whose interactions with amyloid precursor protein (APP) have been extensively explored. Amyloid-β peptides triggering AD are products of APP cleavage by secretases, which differ depending on the APP and secretase location relative to ordered or disordered membrane microdomains. We used high-resolution NMR to probe the interactions of the cholesterol analog with APP transmembrane domain in two membrane-mimicking systems resembling ordered or perturbed lipid environments (bicelles/micelles).
View Article and Find Full Text PDFComparative Study of Bulgarian Linden Honey ( sp.).
Foods
January 2025
Department of Economics, Entrepreneurship and Management, Faculty of Economics, University of Food Technologies, 26 Maritza Blvd., 4002 Plovdiv, Bulgaria.
The present study aims to evaluate and compare some of the main indicators characterizing Bulgarian linden honey depending on the geographical origin. A total of 18 samples were collected from the six regions of Bulgaria, with 3 samples from each region taken from different producers during the 2023 harvest. The physicochemical indicators: hydroxymethylfurfural content, diastase activity, pH, color, water content and electrical conductivity, as well as organoleptic and pollen characteristics, were analyzed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!