The carcinogenic activity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), a pyrolysis product of tryptophan, was studied in inbred strain ACI rats. Twenty rats received a diet containing 0.01% Trp-P-2 for 870 days. Nineteen rats survived for more than 400 days after the start of feeding, 1 rat developed a hemangioendothelial sarcoma of the liver, and 6 rats developed neoplastic liver nodules. These liver tumors were found only in female rats that died 666--870 days after the start of feeding. No liver tumors were found in control animals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0304-3835(81)90082-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of di-(2-ethylhexyl) phthalate in cancer initiation and progression: Mechanisms and health implications.
Sci Total Environ
January 2025
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China. Electronic address:
The increasing prevalence of cancer has been linked to various environmental factors associated with modern industrial and societal advancements. Di-(2-ethylhexyl) phthalate (DEHP), a commonly used plasticizer, is one such environmental contaminant with potential carcinogenic effects. While epidemiological studies have suggested a positive association between DEHP exposure and cancer risk, the specific role of DEHP in cancer initiation and progression requires further clarification.
View Article and Find Full Text PDFDesign, synthesis, and biological evaluation of novel FGFR1 PROTACs.
Bioorg Chem
December 2024
Jiangsu Key Laboratory of Drug Design & Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:
Dysregulation of the fibroblast growth factor receptor 1 (FGFR1) signaling has prompted efforts to develop therapeutic agents, which is a carcinogenic driver of many cancers, including breast, prostate, bladder, and chronic myeloid leukemia. Despite significant progress in the development of potent and selective FGFR inhibitors, the long-term efficacy of these drugs in cancer therapy has been hampered by the rapid onset of acquired resistance. Therefore, more drug discovery strategies are needed to promote the development of FGFR-targeted drugs.
View Article and Find Full Text PDFQuantitative analysis and risk assessment of heavy metal pollution in an intensive industrial and agricultural region.
Ecotoxicol Environ Saf
January 2025
Environment Research Institute, Shandong University, Qingdao, China. Electronic address:
In recent decades, the study of heavy metal pollution has garnered significant attention owing to the advancement of industrialization. To explore the contamination of heavy metals in an intensive industrial and agricultural region in Shandong province, China, 101 surface soil samples and 80 samples of edible crop parts were collected from the vicinity of an industrial park. A positive matrix factorization-multilayer perceptron model (PMF-MLP) was established to identify the sources of heavy metals and quantify the complex relationships between pollution sources, crop types, and pollution status.
View Article and Find Full Text PDFQuantitative source apportionment and health risk assessment for polycyclic aromatic hydrocarbon and their derivatives in indoor dust from housing and public buildings of a mega-city in China.
J Hazard Mater
December 2024
School of Environment, Nanjing Normal University, Jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology, Nanjing 210023, China. Electronic address:
Indoor dust can adsorb various pollutants and long-term deposition can significantly impact air quality and human health. This study investigated the occurrence, source apportionment, and health risks associated with polycyclic aromatic hydrocarbons (PAHs) and their derivatives (d-PAHs) in indoor dust, by focusing on residential and public buildings in Nanjing, China. The concentration of 16 PAHs and 27 d-PAHs ranged from 511 to 5472 ng/g and from 422 to 2904 ng/g, with the most abundant compounds being fluoranthene and 1,2-benz[a]anthraquinone, respectively.
View Article and Find Full Text PDFTopological analysis and predictive modeling of amino acid structures with implications for bioinformatics and structural biology.
Sci Rep
January 2025
Department of Mathematics, College of Natural and Computational Sciences, Wollega University, Nekemte, Ethiopia.
Amino acids, as the fundamental constituents of proteins and enzymes, play a vital role in various biological processes. Amino acids such as histidine, cysteine, and methionine are known to coordinate with metal ions in proteins and enzymes, playing critical roles in their structure and function. In metalloproteins, metal ions are often coordinated by specific amino acid residues, contributing to the protein's stability and catalytic activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!