From own examinations a survey of data concerning morbidity and genealogy of haemophilia is presented. Their comparison with data from literature shows that the total number of haemophiliacs referred to the population (1 : 11,000 males) and the relation of haemophilia A : B (4.5 : 1) vastly corresponds in the middle and north European area. The total number of haemophiliacs which is to be expected for a larger space can approximately be estimated, e. g. for the GDR the number amounts to about 1,200 to 1,300 haemophiliacs. Till now this number has not yet been obtained. At a high percentage the manifestation of the disease takes place in the first two years of life. The greatest number of the haemophiliacs is at present 25 to 40 years old. The fertility rate is clearly different between haemophilia A (0.33) and B (0.84). The number of the female conductors of all variants is certainly double the number as that of the haemophiliacs.
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Orthop Surg
November 2024
Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Glob Health Med
April 2024
Department of Cardiology, National Centre for Global Health and Medicine, Tokyo, Japan.
An extremely high prevalence (12.2%) of moderate-to-severe coronary artery stenosis (CAS) was documented in asymptomatic Japanese haemophiliacs living with HIV-1 (JHLH) in our previous study. The cause of this phenomenon remains unknown.
View Article and Find Full Text PDFIntroduction: Haemophilia affects a large number of people all over the world, yet very little is known about the clinical manifestations and diagnostic protocols of the condition in areas with limited access to resources in developing countries. Understanding the clinical spectrum and diagnostic approach will help with the design of measures to address the situation in these places. The primary objective of this study was to examine the clinicopathological parameters of haemophiliac patients.
View Article and Find Full Text PDFOrphanet J Rare Dis
May 2023
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Hemophilia is an inherited bleeding disorder caused by deficiency of a specific coagulation factor. Factor VIII deficiency is responsible for hemophilia A while factor IX deficiency is responsible for hemophilia B. As per the 2020 annual global survey by the World Federation of Hemophilia, only 1828 Thai hemophiliacs have been registered to the national healthcare system.
View Article and Find Full Text PDFJ Thromb Haemost
June 2023
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, Chinese Academy of Medical Sciences Key Laboratory of Gene Therapy for Blood Diseases, Tianjin, China. Electronic address:
Background: Bleeding episodes in hemophiliacs with inhibitors are difficult to control. Staidson protein-0601 (STSP-0601), a specific factor (F)X activator purified from the venom of Daboia russelii siamensis, has been developed.
Objectives: We aimed to investigate the efficacy and safety of STSP-0601 in preclinical and clinical studies.
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