Changes in the histological structure of endometrial adenoacanthoma, as a result of treatment with 17 alpha-hydroxyprogesterone capronate, are discussed. The biopsy and resected material obtained from 11 patients was studied. It was shown that hormono-therapy results in an increased structural and functional differentiation of the glandular and squamous-cell components of tumor. Sensitivity to 17 alpha-hydroxyprogesterone capronate was established in 81.1% +/- 11.6 of patients.
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