Studies were conducted on 10,261 subjects who had undergone checkups in an AMHTS (Automated Multiphasic Health Testing and Services) Center in the Tokai University Hospital. The breakdown of the screening at the time of the examinations was 48% abnormal and 52% borderline or normal. The disease ratio obtained in follow-up survey averaged 16% and increased as the subjects became older. There were 68 cancer patients, 0.7% of the total number of examinees, and it was found that 88% of the cancer cases definitely diagnosed as cancer within one year after the examinations received these diagnoses within three months from the day of the examinations.
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J Clin Oncol
January 2025
Breast Surgery, Kyoto University Graduate School of Medicine, Shogoin Sakyo-ku, Kyoto, Japan.
In the primary analysis of the open-label phase III PRECIOUS study, pertuzumab retreatment combined with trastuzumab plus chemotherapy of physician's choice (PTC) significantly improved investigator-assessed progression-free survival (PFS) compared with trastuzumab plus physician's choice chemotherapy (TC) in patients with human epidermal growth factor receptor 2 (HER2)-positive locally advanced/metastatic breast cancer (LA/mBC). Here, we report final overall survival (OS) at the median follow-up of 25.8 months.
View Article and Find Full Text PDFJ Hand Surg Eur Vol
January 2025
Department of Human Enhancement and Hand Surgery, Nagoya University, Nagoya, Aichi, Japan.
Digital transformation through extended reality (xR)-comprising virtual, augmented, mixed, and substitutional reality-has become an integral part of the future of clinical and surgical practice. xR technologies facilitate advanced surgical planning, training, therapies and education, reshaping both personal and institutional healthcare. This paper examines the potential changes that xR has introduced into the field of hand surgery, exploring how xR enhances patient-centric care, increases medical service efficiency and revolutionizes surgical training, planning and therapeutic interventions.
View Article and Find Full Text PDFMicroPubl Biol
January 2025
Shimane University, Matsue, Shimane, Japan.
Although cephalopods are primarily polyandrous, genetic evidence revealed rare monogamy in . Here, we studied the sister species . We found that copulation began in early July, with egg spawning occurring in early August.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Earth Science, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
The compression behavior of iron oxyhydroxide ε-FeOOH is complex, with variations in its magnetic property and bonding character. In this study, in situ powder neutron diffraction experiments were conducted on ε-FeOOH and ε-FeOOD up to pressures exceeding 20 GPa to investigate a spin-reorientation (spin-flop) transition, hydrogen-bond (H-bond) symmetrization, and their correlation. The magnetic transition was observed at 8 GPa in both ε-FeOOH and ε-FeOOD.
View Article and Find Full Text PDFDrug Metab Pharmacokinet
December 2024
Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.
This study explored the evolving landscape of Microphysiological Systems (MPS), with a focus on organoids and organ-on-a-chip (OoC) technologies, which are promising alternatives to animal testing in drug discovery. MPS technology offers in vitro models with high physiological relevance, simulating organ function for pharmacokinetic studies. Organoids composed of 3D cell aggregates and OoCs mimicking in vivo environments based on microfluidic platforms represent the forefront of MPS.
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