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Biomedicines
October 2022
Institute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Vascular calcification is a systemic disease contributing to cardiovascular morbidity and mortality. The pathophysiology of vascular calcification involves calcium salt deposition by vascular smooth muscle cells that exhibit an osteoblast-like phenotype. Multiple conditions drive the phenotypic switch and calcium deposition in the vascular wall; however, the exact molecular mechanisms and the connection between vascular smooth muscle cells and other cell types are not fully elucidated.
View Article and Find Full Text PDFInt J Mol Sci
February 2022
Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium.
Pseudoxanthoma elasticum (PXE) is an intractable Mendelian disease characterized by ectopic calcification in skin, eyes and blood vessels. Recently, increased activation of the DNA damage response (DDR) was shown to be involved in PXE pathogenesis, while the DDR/PARP1 inhibitor minocycline was found to attenuate aberrant mineralization in PXE cells and zebrafish. In this proof-of-concept study, we evaluated the anticalcifying properties of minocycline in mice, an established mammalian PXE model.
View Article and Find Full Text PDFArtif Organs
November 2020
Braile Biomédica Ind. Com. e Repres. Ltda., São Paulo, Brazil.
The objective of this study was to evaluate the effect of chemical treatment with glutamic acid to avoid calcification of biological cardiac valves. The bovine pericardium (BP) tissues were fixed with 0.5% glutaraldehyde (BP/GA), followed by treatment with glutamic acid (BP/GA + Glu) for neutralization of the free aldehyde groups.
View Article and Find Full Text PDFJ Ayurveda Integr Med
April 2019
Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand, 263136, India.
Background: Urolithiasis is a burgeoning disease that results from pathological biomineralization. Daucus carota L. is a widely consumed food crop with reported nephroprotective and diuretic activity.
View Article and Find Full Text PDFProtein J
May 2009
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173215, India.
Recurrence and persistent side effects of present day treatment for urolithiasis restrict their use, so an alternate, using phytotherapy is being sought. Dolichos biflorus seeds, which are used as dietary food in India, possess antilithiatic properties. In the present study, a novel dimeric antilithiatic protein (98 kDa) from its seeds was purified based on its ability to inhibit calcium oxalate crystallization in vitro.
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