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Quality of life in patients with progressive keratoconus treated with corneal collagen crosslinking.
Int Ophthalmol
March 2025
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Purpose: This study aims to analyze the vision-related quality of life (vr-QoL) in keratoconus (KC) patients after corneal crosslinking (CXL).
Methods: A prospective clinical study was conducted, wherein 41 patients underwent assessment using the "National Eye Institute Visual Functioning Questionnaire" (NEI-25) and the "Keratoconus Outcomes Research Questionnaire" (KORQ) to evaluate vr-QoL, along with the examination of morphology and functional parameters before CXL, and at three and six months post-treatment. Rasch analyses were used to verify the measurement precision of the KORQ with our study population.
Phototherapeutic activity of polypyridyl ruthenium(II) complexes through synergistic action of nitric oxide and singlet oxygen.
Dalton Trans
March 2025
Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
In recent years, photodynamic therapy (PDT) and gas therapy (GT) have emerged as research hotspots due to their excellent cancer treatment efficacy. By combining the advantages of both, the simultaneous and controllable release of reactive oxygen species (ROS) and nitric oxide (NO) has become a possibility. This paper describes the design of two Ru(II) complexes, [Ru(bpy)(NFIP)](PF) (Ru1, bpy = 2,2'-bipyridine, NFIP = 4-nitro-3-trifluoromethylaniline-1-imidazo[4,5-][1,10]phenanthroline) and [Ru(phen)(NFIP)](PF) (Ru2, phen = 1,10-phenanthroline), through the integration of the polypyridyl ruthenium structure and a photoresponsive NO donor.
View Article and Find Full Text PDFStudy on Mechanical Properties, Optical Properties, Cytotoxicity of TiO-HAP Nanoparticles-Modified PMMA and Photodynamically Assisted Antibacterial Activity Against Candida Albicans in Vitro.
Int J Nanomedicine
March 2025
Department of Oral Prosthodontics, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, People's Republic of China.
Statement Of Problem: The high recurrence rate of denture stomatitis may be related to the strong resistance of fungi. Therefore, the method of providing biomaterials with antifungal properties is an attractive solution for improving microbial control.
Purpose: Against the drug resistance of Candida albicans, this study aim to elucidate the photocatalytic antibacterial effect of TiO-HAP nanocomposite-modified PMMA on Candida albicans through in vitro experiments, and to evaluate the potential impact of the mechanical properties, optical properties, cytotoxicity and contact angle of the modified PMMA, to provide a scientific basis for the development of denture base resins with minimum percentage of photocatalytic additives.
Understanding laser interactions with subcellular compartments is crucial for advancing optical microscopy, phototherapy, and optogenetics. While continuous-wave (CW) lasers rely on linear absorption, femtosecond (fs) lasers enable nonlinear multiphoton absorption confined to the laser focus, offering high axial precision. However, current fs laser delivery methods lack the ability to target dynamic molecular entities and automate target selection, limiting real-time perturbation of biomolecules with mobility or complex distribution.
View Article and Find Full Text PDFHarnessing Nanoreactors with Coupled Optical and Molecular Modalities for Photoenzymatic Modulation of Active Species in Cancer Photo-Immunotherapy.
Small
March 2025
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing, 400044, China.
The dynamic process in tumor ablation requires both the generation of reactive oxygen species (ROS) to elicit immunogenic cell death (ICD) and the subsequent reduction of ROS levels to maintain the stimulatory activity of signaling proteins and recover T cells' immune function. Inspired by the regulation mechanism of redox homeostasis in myeloid-derived suppressor cells and the high-selectivity in alcohols/aldehydes conversions of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and Fe(III) synergistic catalysis, photoenzymatic modulators with contradictory but synergistic functions are developed for adaptive photo-immunotherapy of cancer. In particular, poly(caffeic acid) (PCA) nanospheres are synthesized by highly efficient oxidative polymerization of CA.
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