Responses of the accessory motoneurons to electrical stimulation of he ipsilateral Deiters nucleus were recorded intracellularly in cats under chloralose-nembutal anesthesia. Stimulation of the Deiters nucleus evoked monosynaptic EPSP with latency from 1.3 to 2.3 ms, maximal amplitude 5.0 mV and duration from 7.0 to 10.0 ms in accessory motoneurons. Under rhythmic stimulation the EPSP were weakly potentiated and under increase in te strength of the Deiters stimuli they easily became action potentials.
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J Neurosci
January 2025
Departments of Mechanical Engineering, University of Rochester, Rochester, New York 14627
The mammalian cochlea amplifies sounds selectively to improve frequency resolution. However, vibrations around the outer hair cells (OHCs) are amplified nonselectively. The mechanism of the selective or nonselective amplification is unknown.
View Article and Find Full Text PDFHear Res
March 2024
Department of Otolaryngology, Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, 630 West 168th Street, New York City, NY 10032, USA; Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York City, NY 10027, USA. Electronic address:
Auditory sensation is based in nanoscale vibration of the sensory tissue of the cochlea, the organ of Corti complex (OCC). Motion within the OCC is now observable due to optical coherence tomography. In a previous study (Cooper et al.
View Article and Find Full Text PDFChembiochem
January 2024
Department of Chemical and Biomolecular Engineering, North Carolina State University, Campus Box 7905, 911 Partners Way, Raleigh, NC, 27695, USA.
Stress-activated signaling pathways orchestrate cellular behaviors and fates. Studying the precise role(s) of stress-activated protein kinases is challenging, because stress conditions induce adaptation and impose selection pressure. To meet this challenge, we have applied an optogenetic system with a single plasmid to express light-activated p38α or its upstream activator, MKK6, in conjunction with live-cell fluorescence microscopy.
View Article and Find Full Text PDFInt J Mol Sci
June 2023
Departamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Seville, Spain.
BDNF is a neurotrophin family member implicated in many different neuronal functions, from neuronal survival during development to synaptic plasticity associated with processes of learning and memory. Its presence in the oculomotor system has previously been demonstrated, as it regulates afferent composition of extraocular motoneurons and their firing pattern. Moreover, BDNF expression increases after extraocular motoneuron partial deafferentation, in parallel with terminal axon sprouting from the remaining axons.
View Article and Find Full Text PDFGenes Dev
June 2023
Department of Genetics and Development, Columbia University, New York, New York 10032, USA;
The consolidation of unambiguous cell fate commitment relies on the ability of transcription factors (TFs) to exert tissue-specific regulation of complex genetic networks. However, the mechanisms by which TFs establish such precise control over gene expression have remained elusive-especially in instances in which a single TF operates in two or more discrete cellular systems. In this study, we demonstrate that β cell-specific functions of NKX2.
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