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BMI-mediated association between glyphosate exposure and increased risk of atherosclerotic heart disease: A large-scale cross-sectional study.
PLoS One
January 2025
Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, the association between glyphosate and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims to explore the effect of glyphosate exposure on ASCVD.
View Article and Find Full Text PDFArsenic accumulation and reproductive toxicity in freshwater snail (Pomacea canaliculata).
Ecotoxicol Environ Saf
January 2025
Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China. Electronic address:
This study aimed to investigate the tissue-specific accumulation patterns of arsenic (As) and the potential toxicological effects of As on the oviposition of a globally distributed aquatic invertebrate, the apple snail (Pomacea canaliculata). An eight-compartment physiologically based pharmacokinetic (PBPK) model was utilized to simulate the distribution and depuration kinetics of arsenite and arsenate in the snails. Modeling and biotransformation suggested that intestine-stomach was the main uptake site for As and plays an important role in maintaining the balance of As species.
View Article and Find Full Text PDFGender-Specific Toxic Effects of S-Metolachlor and Its Metabolite on Hibernating Lizards: Implications for Reproductive Health and Ecosystem Vulnerability.
Toxics
November 2024
Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China.
Reptiles rely on hibernation to survive harsh winters, but climate change and pesticide use in agriculture jeopardize their survival, making the ecosystem vulnerable. S-metolachlor (SM), a commonly found herbicide in soil, and its metabolite metolachlor oxanilic acid (MO) induce oxidative stress and disrupt reproductive hormones. In this study, lizards were exposed to SM- and MO-contaminated soil for 45 days during hibernation.
View Article and Find Full Text PDFNeurotoxicity Assessment of Amicarbazone Using Larval Zebrafish.
Toxics
October 2024
Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 04763, Republic of Korea.
Article Synopsis
- - Amicarbazone (AMZ) is a triazolinone herbicide that inhibits photosystem II in plants, leading to weed death but may also have unknown effects on aquatic life.
- - A study on zebrafish embryos and larvae exposed to AMZ showed significant developmental issues such as lower survival rates, more malformations, and decreased heart rates, especially at higher concentrations.
- - Behavioral tests indicated reduced movement in zebrafish, along with disruptions in motor axon formation and important neurodevelopmental pathways, raising concerns about AMZ's neurotoxic effects and the need for more research on its ecological consequences.
Cellular mechanism of polarized auxin transport on fruit shape determination revealed by time-lapse live imaging.
Plant Reprod
November 2024
State Key Laboratory of Plant Diversity and Specialty Crops, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun, Xiangshan, Beijing, 100093, China.
Polarized auxin transport regulates fruit shape determination by promoting anisotropic cell growth. Angiosperms produce organs with distinct shape resultant from adaptive evolution. Understanding the cellular basis underlying the development of plant organ has been a central topic in plant biology as it is key to unlock the mechanisms leading to the diversification of plants.
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