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[Disseminated toxoplasmosis confirmed by tachyzoites and cysts in bone marrow smear after cord blood transplantation].
Rinsho Ketsueki
November 2024
Division of Hematology, Department of Medicine, Showa University School of Medicine.
Article Synopsis
- * Imaging tests revealed multiple brain and lung nodules, and blood tests indicated symptoms consistent with hemophagocytic syndrome.
- * A bone marrow examination confirmed the presence of Toxoplasma gondii, leading to treatment; however, the patient ultimately developed multiple organ failure and died shortly after admission.
Role of auto-antibodies in the mechanisms of dengue pathogenesis and its progression: a comprehensive review.
Arch Microbiol
April 2024
Virology Laboratory, DAC Regional Research Institute, Kolkata, India.
A complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome. Hemostasis, thrombocytopenia, hepatic endothelial dysfunction, and autoimmune blistering skin disease (pemphigus) are different clinical manifestations of dengue pathogenesis; produced due to the molecular mimicry of DENV proteins with self-antigens like coagulation factors, platelets and endothelial cell proteins.
View Article and Find Full Text PDFAn Evaluation of Hemostatic Dysregulation in Canine Multicentric Lymphoma.
Animals (Basel)
February 2024
Division of Internal Medicine, San Marco Veterinary Clinic, 35030 Veggiano, Italy.
Multiple hemostatic abnormalities are associated with paraneoplastic syndrome and some malignant tumors. Lymphoma is the most common hematopoietic neoplasm in dogs, sometimes associated with hemostatic changes. The objectives of this study were to evaluate the behavior of coagulation parameters in dogs with multicentric lymphoma compared with diseased dogs without lymphoma, to separately evaluate the effect of immunophenotype (B lymphoma versus T lymphoma) on the variables of interest as well as the effect of disease stage (stage II to IV versus stage V).
View Article and Find Full Text PDFLevels of peripheral blood routine, biochemical and coagulation parameters in patients with hemorrhagic fever with renal syndrome and their relationship with prognosis: an observational cohort study.
BMC Infect Dis
January 2024
Center for Infectious Diseases, the Second Affiliated Hospital of Air Force Medical University, 569 Xinsi Rd, Baqiao District, Xi'an, 710038, Shaanxi, China.
Background: Hantaan virus (HTNV), Seoul virus (SEOV) and Puumala virus (PUUV) are major serotypes of the Hantavirus, which can cause hemorrhagic fever with renal syndrome (HFRS). The pathophysiology of HFRS in humans is complex and the determinants associated with mortality, especially the coagulation and fibrinolysis disorders, are still not been fully elucidated. Severe patients usually manifest multiple complications except for acute kidney injury (AKI).
View Article and Find Full Text PDFIntravenous Ascorbic Acid for the Prevention of Postreperfusion Syndrome in Orthotopic Liver Transplantation: Protocol for a Randomized Controlled Trial.
JMIR Res Protoc
December 2023
Department of Liver Surgery, Instituto Ramon y Cajal de Investigacion Sanitaria, Hospital Universitario Ramon y Cajal, Madrid, Spain.
Background: Liver transplantation is the last therapeutic option for patients with end-stage liver disease. Postreperfusion syndrome (PRS), defined as a fall in mean arterial pressure of more than 30% within the first 5 minutes after reperfusion of at least 1 minute, can occur in liver transplantation as a deep hemodynamic instability with associated hyperfibrinolysis immediately after reperfusion of the new graft. Its incidence has remained unchanged since it was first described in 1987.
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