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Combined use of 5-ALA-induced protoporphyrin IX and chlorin e6 for fluorescence diagnostics and photodynamic therapy of skin tumors.
Lasers Med Sci
October 2024
Prokhorov General Physics Institute, Moscow, Russian Federation.
Different types of photosensitizers (PSs) have different dynamics and intensities of accumulation, depending on the type of tumor or different areas within the same tumor. This determines the effectiveness of fluorescence diagnostics and photodynamic therapy (PDT). This paper studies the processes of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) and chlorin e6 (Ce6) accumulation in the central and border zones of a tumor after combined administration of two PSs into the patient's body.
View Article and Find Full Text PDFTHE BRONCHOPULMONARY SYSTEM DAMAGE UNDER THE INFLUENCE OF IONIZING RADIATION EXPOSURE AND RADIONUCLIDES INHALATION IN THE CONDITIONS OF THE CHORNOBYL CATASTROPHE (SUMMARIZING OF 35 YEARS RESEARCH EXPERIENCE).
Probl Radiac Med Radiobiol
December 2021
State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
The review is devoted to the summarizing of 35 years of research of ionizing radiation exposure and radionuclidesinhalation influence on the bronchopulmonary system of clean-up workers of the Chornobyl NPP accident. Radiationand hygienic preconditions for the formation of chronic respiratory pathology are considered, taking into accountthe dosimetric data of irradiation of the bronchopulmonary system.The main clinical symptoms, features of disorders of pulmonary ventilation capacity and endoscopic forms of lesionsof the bronchopulmonary system of participants in the liquidation of the accident were determined.
View Article and Find Full Text PDFInfluence of neoadjuvant chemoradiotherapy for locally advanced cervical cancer.
Pol Merkur Lekarski
December 2020
Kharkiv National Medical University, Kharkiv, Ukraine.
Unlabelled: Over the past decade, there are significant advances in the problem of studying the pathogenesis, clinical course and treatment of cervical cancer (CC). Namely the need for more favorable treatment outcomes for locally advanced cervical cancer requires the development of more effective treatments.
Aim: The aim of our work was to study the consequences of neoadjuvant chemoradiation therapy (NCRT) in the management of locally advanced cervical cancer by assessing morphological changes in the tumor tissue.
Моlecular mechanisms of initiation of carcinogenesis in the testis.
Exp Oncol
September 2019
Institute of Urology, NAMS of Ukraine, Kyiv 04053, Ukraine.
In this review, literature data on the study of precancerous changes in testicular tissue and molecular changes, as well as the influence of environmental factors that can initiate carcinogenesis, were analyzed and summarized for the future determination of early diagnosis of germ cell tumors of the testis and the development of preventive measures. The review also discusses the significant new changes presented in the Fourth Edition of the World Health Organization Classification of Urogenital Tumors, published in 2016, and modern concepts of the etiology and pathogenesis of these diseases. Among the environmental factors that can initiate carcinogenesis, the most noteworthy are the biological effects of low doses of ionizing radiation, such as the effect of radiation-induced genome instability, which increases the risk of carcinogenesis, the "bystander effect", and chronic oxidative stress.
View Article and Find Full Text PDFTwenty five years of the National Academy of Medical Sciences of Ukraine - progress and priorities for future of radiation medicine and biology.
Probl Radiac Med Radiobiol
December 2017
State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Melnykova str., 53, Kyiv, 04050, Ukraine.
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population.
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