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Angiotensin 1-7 injected into the rat paraventricular nucleus of hypothalamus increases blood pressure and heart rate via various receptors.
Neuropharmacology
December 2024
Department of Experimental Physiology and Pathophysiology, Medical University of Białystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
Although angiotensin 1-7 (Ang 1-7) and its role as a part of the "protective" axis of the renin-angiotensin system are well described in the literature, the mechanisms of its angiotensin II-like pressor and tachycardic effects following its acute central administration are not fully understood. It was the aim of the present study to examine which receptors contribute to the aforementioned cardiovascular effects. Ang 1-7 and antagonists for glutamate, GABA, vasopressin, thromboxane A (TP), α-adrenergic, and P2X purinoceptors or modulators of oxidative stress were injected into the paraventricular nucleus of the hypothalamus (PVN) of urethane-anesthetized male Wistar rats.
View Article and Find Full Text PDFA Self-Cascading Catalytic Therapy and Antigen Capture Scaffold-Mediated T Cells Augments for Postoperative Brain Immunotherapy.
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December 2024
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.
The recruitment of T lymphocytes holds great potential for suppressing the most aggressive glioblastoma (GBM) recurrence with immunotherapy. However, the phenomenon of immune privilege and the generally low immunogenicity of vaccines often reduce the presence of lymphocytes within brain tumors, especially in brain tumor recurrence clusters. In this study, an implantable self-cascading catalytic therapy and antigen capture scaffold (CAS) that can boost catalytic therapy efficiency at post-surgery brain tumor and capture the antigens via urethane-polyethylene glycol-polypropylene glycol (PU-EO-PO) segments are developed for postoperative brain immunotherapy.
View Article and Find Full Text PDF2D Polyamides Enable Self-Healing and Recyclable Elastomers with High Robustness, Toughness, and Crack Resistance via Supramolecular Interactions.
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December 2024
Key Laboratory of New Processing Technology for Nonferrous Metal and Materials, Ministry of Education, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, Guangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, College of Material Science and Engineering, Guilin University of Technology, Guilin, Guangxi, 541004, China.
High-performance elastomers with exceptional mechanical properties and self-healing capabilities have garnered significant attention due to their wide range of potential applications. However, designing elastomers that strike a balance between self-healing capabilities and mechanical properties remains a considerable challenge. Inspired by biological cartilage, a highly robust, tough, and crack-resistant self-healing elastomer is presented by incorporating hydrogen-bond-rich 2D polyamide (2DPA) into a poly(urethane-urea) matrix.
View Article and Find Full Text PDFSynergistic antitumor effects of atorvastatin and chemotherapies: In vitro and in vivo studies.
Biochem Biophys Res Commun
January 2025
Research Lab. of Molecular Carcinogenesis, Zoology Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Atorvastatin (ATOR) acts on certain antitumor pathways; the consequences of chemotherapies continue to be a major concern, notwithstanding the increased efficacy provided by contemporary therapies. This study investigated the synergistic effects and underlying mechanisms of different treatment protocols using ATOR on the THP-1 cell line and on lung cancer in mice. For the in vitro study, an MTT assay was performed, and then different combinations against the THP-1 cell line were used as follows: non-treated cells, THP-1/ATOR IC, THP-1/cytarabine (CYT) IC, THP-1/doxorubicin (DOX) IC, THP-1/DOX/CYT, THP-1/ATOR/CYT, THP-1/ATOR/DOX, and THP-1/ATOR/CYT/DOX.
View Article and Find Full Text PDFSustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion.
Adv Sci (Weinh)
December 2024
Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Rd., Shanghai, 200233, P. R. China.
Persistent anti-inflammatory responses are critical for the prevention of peritendinous adhesion. Although modified anti-adhesion barriers have been studied extensively, the immune response induced by the implants and the unclear mechanism limits their application. In this research, the advantage of the multi-functionalities of CA (caffeic acid) is taken to synthesize biodegradable poly (ester urethane) urea elastomers with ester- and carbamate-bonded CA (PEUU-CA).
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