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Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach.
Mar Drugs
December 2024
Graduate Program in Biochemistry and Molecular Biology, Center of Biosciences, Federal University of Rio Grande do Norte-UFRN, Av. Sen. Salgado Filho, 3000, Natal 59078-900, Brazil.
Carrageenans have demonstrated enhanced antitumor activity upon depolymerization into disaccharides. However, the pharmacological viability of these disaccharides and their mechanisms of antitumor action remains to be fully elucidated. This study aimed to employ computational tools to investigate the pharmacological properties and molecular targets pertinent to cancer of the disaccharides derived from the primary carrageenans.
View Article and Find Full Text PDFSeaweed-Derived Bioactive Compounds: Potent Modulators in Breast Cancer Therapy.
Chem Biodivers
December 2024
Department of Chemistry, IIT Bombay, Mumbai, India.
Cancer remains a major global health concern, with breast cancer being particularly challenging. To address this, new therapeutic strategies are being explored, including natural alternatives. Seaweeds, rich in bioactive compounds, have gained attention for their therapeutic potential.
View Article and Find Full Text PDFElimination of Ethanol for the Production of Fucoidans from Brown Seaweeds: Characterization and Bioactivities.
Mar Drugs
October 2024
Department of Food Chemistry & Technology, Teagasc Food Research Centre, D15 DY05 Dublin, Ireland.
Fucoidan, a sulphated polysaccharide from brown seaweed composed of several monosaccharides, has been stated to have several bioactive properties such as antioxidant, antiviral, anticancer, antithrombic, anti-inflammatory, and immunomodulatory effects. This paper provides research findings on green extraction methods, structural analysis of fucoidan, and its associated bioactivities. Fucoidans from brown seaweeds, and were extracted using green solvents such as citric acid (CA) followed by MWCO (molecular weight cut-off) filtration to obtain high-purity polysaccharides.
View Article and Find Full Text PDFFucoidan from Enhances Exercise Performance and Increases the Abundance of Beneficial Gut Bacteria in Mice.
Mar Drugs
October 2024
School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia.
Article Synopsis
- * In a study with C57BL/6J mice, fucoidan supplementation (400 mg/kg/day) over 10 weeks increased daily running distance by 25.5% and muscle mass by 10.4%, with positive effects on gut microbiome health.
- * The supplementation also enhanced the expression of genes related to mitochondrial function, suggesting fucoidans may improve exercise performance and recovery by supporting beneficial gut bacteria and muscle function.
Elucidation of anti-human melanoma and anti-aging mechanisms of compounds from green seaweed Caulerpa racemosa.
Sci Rep
November 2024
Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia.
Human melanoma is linked with aging-related disorders, prompting interest in the development of functional foods derived from natural ingredients to mitigate its incidence. Molecules in green seaweeds such as Caulerpa racemosa can serve this purpose due to their anti-tumor and anti-inflammatory properties. A previous work study compounds profiling has been carried out, and in this research the molecular docking studies targeting receptors associated with melanoma (GRP78, IRE1, BRAF) and aging (mTOR, AMPK, SIRT1) identified four promising compound in an extract of C.
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