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Susceptibility to organophosphate insecticides in Aedes aegypti (Diptera: Culicidae) from northern Colombia and associated resistance mechanisms.

Parasit Vectors

January 2025

Facultad de Ciencias de la Salud, Centro de Investigación en Ciencias de la Vida (CICV), Universidad Simón Bolívar, Barranquilla, Colombia.

Background: Aedes aegypti is the primary vector of dengue, chikungunya, and Zika viruses in Colombia. Various insecticides, including pyrethroid, organophosphate, and carbamate insecticides; growth regulators; and biological insecticides, such as Bacillus thuringiensis var. israelensis, have been used to control Ae.

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Seasonal dynamics, resting behaviour and insecticide susceptibility of mosquitoes across two differentially malaria-endemic regions in Ethiopia.

Curr Res Parasitol Vector Borne Dis

October 2024

School of Medical Laboratory Sciences, Faculty of Health Sciences, Jimma University, Jimma, Ethiopia.

Information on bionomics of species composition, seasonal dynamics and insecticide susceptibility status is important to understand malaria transmission in any particular eco-epidemiological setting and for the design of effective vector control strategies. Here, adult mosquitoes were collected using CDC light traps (CDC LTs) and human landing catches (HLC) for 17 months between June 2018 and September 2020 from Lare District of Ethiopia. Larvae and pupae of anopheline mosquitoes were collected from breeding sites of Lare District and Jimma and reared to adulthood.

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Background: To overcome the spread of high pyrethroid resistance in the main malaria vectors and malaria disease persistence, it is crucial to look for effective and better resistance management strategies. Understanding the phenotypic profile of against alternatives insecticides like organophosphates and carbamates is crucial.

Methods: larvae and pupae were collected from the breeding sites in rice fields, pineapple crop areas, and peri-urban areas.

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Article Synopsis
  • * The research involved standard bioassays to assess resistance against various insecticides, along with biochemical tests to identify metabolic resistance mechanisms and real-time PCR for detecting specific genetic mutations (Kdr).
  • * The findings revealed significant resistance levels in multiple strains of Aedes mosquitoes, with notable variation in enzyme activity related to resistance, and identified the presence of Kdr mutations in several populations, indicating a pressing public health challenge.
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Modified landscapes could create breeding habitats for mosquitoes and affect their community structure and susceptibility with implications for their management. Hence, in this study, household mosquito control methods in two urbanized landscapes; industrial and residential human settlements, in Ghana and insecticide susceptibility of the inhabiting populations were assessed. Household knowledge and usage pattern of mosquito control methods in the modified landscapes were obtained using a questionnaire.

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