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Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.
JAMA Netw Open
January 2025
Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.
Objective: To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.
Design, Setting, And Participants: This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]).
Unveiling the Origin of Copper Accumulation in Plasma with Aging.
Environ Health (Wash)
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues.
View Article and Find Full Text PDFInherited metabolic diseases are a potent risk factor for cytomegalovirus infection in pediatric living donor liver transplantation.
BMC Infect Dis
January 2025
Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Tochigi, Japan.
Background: Cytomegalovirus (CMV) is a major infectious complication in solid-organ transplant recipients, particularly in the context of pediatric liver transplantation. CMV serostatus is a well-established risk factor for postoperative CMV infection, with CMV seronegative recipients who receive organs from seropositive donors (D+/R-) being at the highest risk. Our previous research indicated a higher incidence of CMV infection in recipients with inherited metabolic diseases (IMDs) compared with those with biliary atresia (BA).
View Article and Find Full Text PDFImmobilized Saccharomyces cerevisiae viable cells for electrochemical biosensing of Cu(II).
Sci Rep
January 2025
Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.
Electrodes functionalised with weak electroactive microorganisms offer a viable alternative to conventional chemical sensors for detecting priority pollutants in bioremediation processes. Biofilm-based biosensors have been proposed for this purpose. However, biofilm formation and maturation require 24-48 h, and the microstructure and coverage of the electrode surface cannot be controlled, leading to poorly reproducible signal and sensitivity.
View Article and Find Full Text PDFAssessing the seasonality of foliar nutrient concentrations in woody plants.
Ecology
January 2025
CSIC, Global Ecology Unit CREAF-CSIC-UAB, Cerdanyola del Vallès, Catalonia, Spain.
Seasonal variations in foliar nutrient concentrations are an important strategy of plants to adapt to different climates and availabilities of soil nutrients. Gaps in our knowledge, however, remain in both the seasonality of the concentrations of multiple nutrients in plant leaves and their spatial pattern on a large scale. We compiled data on foliar concentrations of nine essential nutrients (N, P, K, Ca, Mg, Fe, Mn, Zn, and Cu) in woody plants in China and evaluated the characteristics and latitudinal patterns of their seasonal variability (i.
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