Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0041-008x(81)90341-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Are Fish Consumption Advisories for the Great Lakes Adequately Protective against Chemical Mixtures?
Environ Health Perspect
April 2017
Department of Physical & Environmental Sciences, University of Toronto, Toronto, Ontario, Canada.
Article Synopsis
- The Great Lakes support over 140 fish species and are important for fishing, but toxic substances have led to health advisories regarding fish consumption.
- This study analyzed whether the current advisories sufficiently account for the additive effects of multiple chemicals, using Ontario’s fish contaminant data.
- Findings suggest that about half of the advisories may be inadequate, especially in Lake Ontario, highlighting the need for stricter guidelines on popular fish like walleye and salmon, while indicating that monitoring of some contaminants may not be necessary.
Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro.
Toxicol Sci
February 2000
Toxicology Research Division, Food Directorate, Health Canada.
In order to produce a reporter gene assay for androgenic chemicals, a constitutive expression vector coding for the human androgen receptor and a reporter construct containing the firefly luciferase coding sequence under transcriptional control of the androgen responsive MMTV promoter were cotransfected into the androgen-insensitive human PC-3 prostate carcinoma cell line and stable transfectants selected. One colony of transfectants, PC-3 LUCAR+, was characterized further. 5alpha-Dihydrotestosterone (DHT) enhanced luciferase activity in a linear fashion for up to 3 days of culture.
View Article and Find Full Text PDFThe effect of photomirex on the in vitro perfused ovary of the rat.
Reprod Toxicol
August 1998
Department of Obstetrics and Gynaecology, University of Calgary, Alberta, Canada.
Photomirex, a photodegradation product of the insecticide mirex, is an environmental contaminant that has been identified in Great Lakes fish, soil, and human adipose tissue. Because of the potential for human exposure, the present study was designed to investigate the short-term effects of photomirex on the in vitro perfused ovary of the rat. Adult Sprague-Dawley rat ovaries were isolated and perfused for a total of 6 h with Medium 199.
View Article and Find Full Text PDFChlorinated hydrocarbons and shell thinning in eggs of (Accipiter) hawks in Ontario, 1986-1989.
Environ Pollut
January 2005
Canadian Wildlife Service, National Wildlife Research Centre, Ottawa, Ontario, Canada K1 A 0H3.
Eggs of sharp-shinned hawks (Accipiter striatus), Cooper's hawks (A. cooperii), and northern goshawks (A. gentilis) were collected from nests in south-central Ontario from 1986 to 1989.
View Article and Find Full Text PDFMechanism of the lethal interaction of chlordecone and CCl4 at non-toxic doses.
Toxicol Lett
December 1989
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216.
There is significant interest in the possibility of unusual toxicity due to interaction of toxic chemicals upon environmental or occupational exposures even though such exposures may involve levels ordinarily considered harmless individually. While many laboratory and experimental models exist for such interactions, progress in this area of toxicology has suffered for want of a model where the interactants are individually non-toxic. We developed such a model where prior exposure to non-toxic levels of the pesticide Kepone (chlordecone) results in a 67-fold amplification of CCl4 lethality in experimental animals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!