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14-3-3 promotes sarcolemmal expression of cardiac Ca1.2 and nucleates isoproterenol-triggered channel superclustering.
Proc Natl Acad Sci U S A
February 2025
Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616.
The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.
View Article and Find Full Text PDFSomatostatin-expressing neurons in the medial prefrontal cortex promote sevoflurane anesthesia in mice.
Anesthesiology
January 2025
Key Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, 563100, Guizhou Province, China.
Background: The medial prefrontal cortex plays a crucial role in regulating consciousness. However, the specific functions of its excitatory and inhibitory networks during anesthesia remain uncertain. Here we explored the hypothesis that somatostatin interneurons in the medial prefrontal cortex enhance the effects of sevoflurane anesthesia by increasing GABA transmission to pyramidal neurons.
View Article and Find Full Text PDFBiophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells.
PLoS Comput Biol
January 2025
School of Mathematical Sciences, Shanghai Jiao Tong University, Shanghai, China.
This study combines experimental techniques and mathematical modeling to investigate the dynamics of C. elegans body-wall muscle cells. Specifically, by conducting voltage clamp and mutant experiments, we identify key ion channels, particularly the L-type voltage-gated calcium channel (EGL-19) and potassium channels (SHK-1, SLO-2), which are crucial for generating action potentials.
View Article and Find Full Text PDFInfluence of heat treatment method on selected physicochemical and biological properties of fluoride-substituted calcium apatite.
Acta Bioeng Biomech
September 2024
Department of Biochemistry and Biotechnology, Medical University of Lublin, Lublin, Poland.
: The synthesis of fluoridated apatite consists of several stages, among which the heat treatment has a significant impact on the physical and chemical properties. The present study aims to elucidate the influence of two different sintering methods on fluoride-substituted apatite properties. : For this purpose, a two F-substituted apatites were produced by heat treatment in different ways called "rapid sintering" and "slow sintering".
View Article and Find Full Text PDFHydration Effects Driving Network Remodeling in Hydrogels during Cyclic Loading.
ACS Macro Lett
January 2025
Materials Science and Engineering Department, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
In complex networks and fluids such as the extracellular matrix, the mechanical properties are substantially affected by the movement of polymers both part of and entrapped in the network. As many cells are sensitive to the mechanical remodeling of their surroundings, it is important to appreciate how entrapped polymers may inhibit or facilitate remodeling in the network. Here, we explore a molecular-level understanding of network remodeling in a complex hydrogel environment through successive compressive loading and the role that noninteracting polymers may play in a dynamic network.
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