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Dual Functional Electroconductive Biofortified Electrospun Scaffold Functionalized With MWCNTs and Bacopa Monnieri for Accelerated Peripheral Nerve Regeneration.
Small
March 2025
Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Peripheral nerve injuries (PNIs) often lead to semi or complete loss of motor, sensory and autonomic functions. Although autografts are still the best option for PNI repair, their use is restricted due to the morbidity and availability of donor nerves. Because electrospun scaffolds may replicate the structure of native extracellular matrix (ECM), they provide a viable alternative.
View Article and Find Full Text PDFLow-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment.
Front Pharmacol
February 2025
Division of Pulmonology, Allergy and Immunology, Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Background: Neurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation. The inhibitory reno-renal reflex, where central integration of renal sensory input reduces sympathetic outflow and systemic BP, presents a promising target for neurostimulation interventions.
View Article and Find Full Text PDFComparison of the Effects of Dexamethasone and Magnesium Sulfate Used as Adjuvants on Infraclavicular Brachial Plexus Nerve Block: A Prospective, Double-Blinded Randomized Controlled Trial.
Cureus
February 2025
Department of Anesthesiology and Reanimation, Faculty of Medicine, Van Yuzuncu Yil University, Van, TUR.
Background This prospective clinical study aims to compare the effectiveness of lower-dose dexamethasone and magnesium sulfate as adjuvants to bupivacaine in ultrasound-guided infraclavicular brachial plexus block for distal upper limb surgery. Materials and methods Ninety patients, aged 18 to 65 years, with American Society of Anesthesiologists (ASA) physical status scores of I or II who underwent distal upper limb surgeries, including the arm, elbow, forearm, and hand surgery under infraclavicular brachial plexus block, were included in the study. The block was performed under ultrasound guidance.
View Article and Find Full Text PDFFrom in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease.
J Tissue Eng
March 2025
University of Limoges, NeurIT UR 20218, GEIST Institute, Limoges, France.
Peripheral neuropathies are disorders affecting the peripheral nervous system. Among them, Charcot-Marie-Tooth disease is an inherited sensorimotor neuropathy for which no effective treatment exists yet. Research on Charcot-Marie-Tooth disease has been hampered by difficulties in accessing relevant cells, such as sensory and motor neurons, Schwann cells, and myocytes, which interact at the neuromuscular junction, the specialized synapses formed between nerves and skeletal muscles.
View Article and Find Full Text PDFManaging a Burning Face: Clinical Manifestations and Therapeutic Approaches for Neurogenic Rosacea.
Int J Mol Sci
March 2025
Escuela de Medicina, Universidad de Tarapacá, Arica 1000000, Chile.
Rosacea is a common chronic inflammatory condition primarily affecting middle-aged women. It presents with flushing, erythema, telangiectasia, papules, pustules, phymatous changes, and ocular involvement. Although typically grouped into four subtypes-erythematotelangiectatic, papulopustular, ocular, and phymatous-overlapping features often favor a phenotypic diagnostic approach.
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