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Efficacy and safety of the combination of anlotinib and envafolimab in the treatment of unresectable or metastatic liposarcoma: findings from a single-center retrospective study.
Front Oncol
January 2025
Department of Hepatobiliary and Pancreatic Surgery & Retroperitoneal Tumor Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Objective: To evaluate the efficacy and safety of anlotinib combined with envafolimab in the treatment of unresectable or metastatic liposarcoma.
Methods: This single-center, retrospective study enrolled 15 patients with unresectable or metastatic liposarcoma, who were treated at the Retroperitoneal Tumor Surgery Research Center of Qingdao University Affiliated Hospital between April 2022 and November 2023. The treatment regimen consisted of anlotinib combined with envafolimab.
Giant Well-Differentiated Liposarcoma of Esophagus Completely Removed by Endoscopic Submucosal Dissection.
Dig Dis Sci
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, 300# Guangzhou Road, Nanjing, Jiangsu Province, China.
Oncogenic Functions of Alternatively Spliced Isoform in Retroperitoneal Liposarcoma.
Int J Mol Sci
December 2024
The James Comprehensive Cancer Center, Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes of soft tissue sarcoma (STS). Complete surgical resection remains the mainstay treatment, while the high rate of locoregional recurrence constitutes the predominant cause of mortality. Well-differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcoma are the most frequent subtypes of RPLPS and present amplified MDM2 gene as a hallmark.
View Article and Find Full Text PDFUnusual Presentation of Large Retroperitoneal Lipoma in a 3-Year-Old Child: A Case Report.
Clin Med Insights Case Rep
January 2025
Department of Radiology, Haramaya University College of Health and Medical Sciences, Harar, Ethiopia.
Background: Lipomas can occur almost anywhere in the body, but they are exceptionally rare in the retroperitoneal region. While lipomas are common in adults, they are quite uncommon in children. Even among adults, retroperitoneal lipomas are not frequently encountered.
View Article and Find Full Text PDFTargeting liposarcoma: unveiling molecular pathways and therapeutic opportunities.
Front Oncol
December 2024
Department of Hepatobiliary and Pancreatic Surgery & Retroperitoneal Tumor Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma.
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