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Relationship between relaxin-2 levels in serum and mode of conception in twin gestations: A prospective cohort study.
J Obstet Gynaecol Res
January 2025
Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Aim: Relaxin is a peptide hormone commonly associated with pregnancy when it is thought to play a role in modulating various physiological processes to optimize maternal-fetal adaptation. In twin pregnancies these adaptive requirements are higher than in singleton pregnancies, therefore it is important to understand how circulating relaxin behaves in such conditions. This prospective cohort study aims to determine the serum relaxin-2 levels throughout gestation in twin pregnancies and to investigate its association with the mode of conception.
View Article and Find Full Text PDFRole of Relaxin Signaling in Cancer: A Review.
Biochem Pharmacol
December 2024
Department of Internal Medicine, Division of Diabetes, Endocrinology, and Metabolism, University of Nebraska Medical Center, Omaha, NE, USA; VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:
The investigation into relaxin (RLN), additional RLN-like proteins, and RLN family peptide receptors (RXFP) has demonstrated their role in modulating the extracellular matrix (ECM), immune cells, specifically macrophages, and angiogenesis, with recent evidence showing an effect on signaling pathways in tumor cells. These findings serve as the basis for our narrative review to collate pertinent studies in this field and provide our perspective on their clinical and investigational significance. In the article, we discuss findings from pertinent studies focusing on evaluating the expression or effect of RLN1, RLN2, or RXFP1 in various cancers.
View Article and Find Full Text PDFYiqi Yangxue formula inhibits cartilage degeneration in knee osteoarthritis by regulating LncRNA-UFC1/miR-34a/MMP-13 axis.
J Ethnopharmacol
January 2025
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China; School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, 650500, China. Electronic address:
Article Synopsis
- Knee osteoarthritis (KOA) is a common and debilitating condition, and the Yiqi Yangxue formula (YQYXF) is often used to treat it, though research on its epigenetic effects and role of non-coding RNA is limited.
- The study investigates how YQYXF impacts the long chain non-coding RNA UFC1, miR-34a, and matrix metalloproteinase-13 (MMP-13), looking at their interactions and significance in KOA.
- Using various methods including UHPLC-QE-MS technology and RT-PCR, researchers found that YQYXF contains key compounds like flavonoids and phenylpropanoids that potentially influence the expression of genes related to
Primary Anterior Cruciate Ligament Injury: Extrinsic and Intrinsic Risk Factors.
J Am Acad Orthop Surg
September 2024
From the Department of Orthopaedic Surgery, UPMC Freddie Fu Sports Medicine Center, University of Pittsburgh, Pittsburgh, PA (Apseloff, Hughes, Musahl), and the Dublin City University, School of Health and Human Performance and Sports Surgery Clinic, Dublin, Ireland (Devitt).
Anterior cruciate ligament (ACL) injuries continue to increase in incidence despite extensive research into prevention strategies. Many extrinsic and intrinsic risk factors for sustaining ACL injuries have been identified and continue to be investigated. Extrinsic risk factors for ACL injury relate to the athlete's environment, such as the shoe-surface interaction, weather conditions, and sport played.
View Article and Find Full Text PDFEngineering and Characterization of a Long-Half-Life Relaxin Receptor RXFP1 Agonist.
Mol Pharm
September 2024
Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.
Relaxin-2 is a peptide hormone with important roles in human cardiovascular and reproductive biology. Its ability to activate cellular responses such as vasodilation, angiogenesis, and anti-inflammatory and antifibrotic effects has led to significant interest in using relaxin-2 as a therapeutic for heart failure and several fibrotic conditions. However, recombinant relaxin-2 has a very short serum half-life, limiting its clinical applications.
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