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Radiotherapy to patients with artificial cardiac pacemakers.
Cancer Treat Rev
October 2005
Department of Oncology, Nottingham City Hospital, Nottingham NG5 1PB, United Kingdom.
Background: The in vitro studies show that the modern cardiac pacemakers utilising the complementary metal-oxide semi-conductor (CMOS) circuitry can be adversely affected by therapeutic radiation. However, the published clinical data are sparse regarding the safety of radiotherapy delivery to patients with artificial pacemakers. Despite the potential risk of life threatening complications, there are no national guidelines and most radiotherapy departments have no formal clinical risk management strategy in place.
View Article and Find Full Text PDFThe initial clinical experience with an implantable cardioverter defibrillator/antitachycardia pacemaker.
Pacing Clin Electrophysiol
July 1991
Cardiovascular Division, University of Louisville, Kentucky 40292.
Guardian antitachycardia pacing (ATP) 4210 is a third generation, multi-programmable cardioverter defibrillator undergoing Phase I clinical trials. The tiered response includes ATP, low energy cardioversion or defibrillation, and bradycardia support. Extensive telemetry is available, including an episode log and details of all episode events.
View Article and Find Full Text PDFUsefulness of rate responsive atrial pacing in patients with sick sinus syndrome.
Pacing Clin Electrophysiol
January 1989
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
We studied heart rate response and blood lactate changes during treadmill exercise testing in 10 patients with sick sinus syndrome (SSS) and normal atrioventricular (AV) conduction in whom an activity detecting multi-programmable rate responsive pacemaker was implanted for atrial pacing (AAI pacing). Treadmill exercise testing was performed twice in each patient under the two different AAI pacing modes: rate responsive function off (fixed rate 60 pulses per minute [ppm]; RR-off) and rate responsive function on (rate response 10, activity threshold medium, basic rate 60 ppm, and maximum rate 150 ppm; RR-on). Chronotropic response and blood lactate change during exercise were compared among patients under each pacing mode and eight healthy volunteers of ages matching those of the patients.
View Article and Find Full Text PDFPacing and the non-invasive evaluation of myocardial fatty acid metabolism by means of 17-123I-heptadecanoic acid scintigraphy.
Nuklearmedizin
October 1988
Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands.
The extent of myocardial non-esterified fatty acid (NEFA) oxidation depends among other things on exogeneous NEFA supply and energy demand. In 6 patients with a multi-programmable pacemaker scintigraphy with 17-123Iodo-heptadecanoic acid (17-123I-HDA) was performed to investigate NEFA metabolism at two levels: at a control level (basal heart rate 69 +/- 6) and at increased pace frequency (104 +/- 5). In both situations the derived time-activity curves, measured during a period of 75 min, were fitted with a monoexponential plus a constant curve: A(t) = A(0).
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