In the experiments intact dog hearts with ligated descendents, hearts with aorta insufficiency and others with a cardiopulmonary bypass were perfused. It was demonstrated that both ischaemia and relative oxygen deficiency induce within a comparatively short time the same type of irreversible damage in the structure of the subendocardial layers of the myocardium (lysis and rupture of the myofilament, swelling of the mitochondrium, rupture and lysis of the crista, clearing of the matrix). Consequently, the aimed protection of the myocardium during cardiac surgery is of the greatest importance.
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Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways.
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From the Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Pacific Theatres Bldg, Ste 400, Los Angeles, CA 90048 (Y.H., L.T.H., H.L.L., D.L., H. Han, A.G.C., H.J.Y.); Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Ind (Y.H., X.G., X.Z., G.Y., G.A., S.F.C., K.P.V., B.S., D.P.S., K.Y., R.D.); Departments of Bioengineering (Y.H., X.Z., A.G.C.) and Statistics (H. Ho), University of California Los Angeles, Los Angeles, Calif; Academia Sinica, Institute of Statistical Science, Nankang, Taipei, Taiwan (H. Ho); Department of Surgery, Division of Neurosurgery, Mackay Memorial Hospital, Taipei, Taiwan (L.T.H.); Department of Medical Imaging, National Cheng Kung University Hospital, Tainan, Taiwan (H.Y.L.); Siemens Medical Solutions USA, Malvern, Pa (X.B., F.H.); and Department of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, Calif (A.G.C.).
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