[Lysosome membrane permeability and chemical teratogens].

The influence of chemical compounds (their action is well studied in application to intrauterine development) on permeability of the lysosome membrane in vitro is studied by the account of the marker enzyme (acid phosphatase--EC 3.1.3.2) activity in the lysosomal fraction and supernatant fluid. It is established that pyrimethamine and pyridine dichlorohydrate 2 (beta-ethyl aminoethyl) in low concentrations stabilize the lysosome membrane, ethonium and dimexide destabilize it, and actinomycin practically has no effect on permeability of the lysosome membrane. The effect of chemical agents on permeability of lysosomes depends on their concentration. The pyrimethamine stabilizing effect relative to the lysosome membranes of liver cells is manifested already 1 hour after the action and persists for 8 days.