Cytoplasmatic processes of human normal cervical epithelium cells and of carcinoma in situ lesions were examined; transmission and scanning electron microscopy were used. Microvilli, microspikes and microplicae were predominant in various layers of normal squamous epithelium. It is suggested that transformation of microvilli into microspikes and then into microplicae accompanied the formation and disassembly of desmosomes in the normal epithelium. Microvilli were found to be the predominant type of cytoplasmatic processes in all the layers of the carcinoma in situ epithelium. It is suggested that the transformation of cytoplasmic processes is deficient in these lesions; this deficiency may be associated with a decreased formation of desmosomes. Possible similarities between pseudopodial attachment processes in vitro and in vivo are discussed.
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