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Self-Care Interventions for Children and Young People With Neurodisabilities: A Mixed Methods Study of Current Therapy Practice in the United Kingdom.
Child Care Health Dev
March 2025
Northumbria University, Newcastle upon Tyne, UK.
Background: Self-care is a priority outcome for children and young people with neurodisabilities, their parents and therapists, but there is little evidence about paediatric therapy interventions for children's self-care in the United Kingdom.
Methods: Children with neurodisabilities, parents, therapists and teachers participated in this mixed methods study. Data were collected by interviews and observations of routine therapy appointments.
Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data.
BMJ Open
March 2025
Department of Renal Medicine, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
Objectives: To evaluate hospital outcomes and their predictors during the pandemic for patients with and without COVID-19, stratified by the presence of acute kidney injury (AKI).
Design: Retrospective observation study using the Hospital Episodes Statistics database for England.
Participants: 2 385 337 unique hospital admissions of adult patients from March 2020 to March 2021 in England.
Calculating Follow-Up Completeness: a comparison of multiple methods under different simulated scenarios and a use-case.
J Clin Epidemiol
March 2025
Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:
Background: Completeness of follow-up is a crucial aspect of data quality in cohort studies and clinical trials. This study aims to provide an overview of different methods to calculate follow-up completeness. Additionally, the performance of these methods is tested in several scenarios using simulated datasets and a use-case, with the aim of guiding researchers in selecting the most appropriate method for their data.
View Article and Find Full Text PDFHigh density lipoproteins and COVID-19: preparing the next pandemic.
J Lipid Res
March 2025
Université de La Réunion, UMR Diabète Athérothrombose Réunion Océan Indien (DéTROI), INSERM U1188, 97410 Saint-Pierre, La Réunion, France; Service de Médecine Interne et Polyvalente, CHU de la Réunion, 97410 Saint-Pierre, La Réunion, France.
High-density lipoproteins (HDLs) are heterogeneous particles with pleiotropic functions including anti-inflammatory and anti-infectious effects. In clinical studies, lower HDL-associated cholesterol (HDL-C) concentration has been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity and mortality. A reduction in the number of HDL particles, particularly small ones has been observed with alterations in their protein and lipid composition impairing their functions.
View Article and Find Full Text PDFTemporal trends in management strategies and clinical outcomes of venous thromboembolism in Japan from 2017 to 2023.
J Cardiol
March 2025
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: Venous thromboembolism (VTE) is a major health problem worldwide. There are scarce data on the recent temporal trends of patients with VTE after the widespread use of direct oral anticoagulants (DOACs).
Methods And Results: In a Japanese nationwide hospital administrative database, we identified 20,217 patients with VTE from 2017 to 2023, and evaluated their temporal trends in management strategies and clinical outcomes.
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