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Role of intermittent hypoxic training combined with methazolamide in the prevention of high-altitude cerebral edema in rats.
Sci Rep
December 2024
Department of Neurosurgery, Neuromedicine Center, Beijing Shijitan Hospital, Capital Medical University, No. 10, Tieyi Road, Yangfangdian, Haidian District, Beijing, 100038, China.
Article Synopsis
- Intermittent hypoxia training (IHT) and methazolamide (MTZ) show limited effectiveness individually in preventing high-altitude cerebral edema (HACE), with few studies exploring their combined use.
- A rat model was developed to study the effects of IHT and MTZ on behavior, brain water content, pathology, and protein expression after exposure to hypobaric hypoxia and exhaustive exercise.
- The combination of long-course IHT and MTZ demonstrated the most significant improvement in spatial and memory function, brain pathology, and protein levels, indicating a potential effective approach for preventing HACE.
Cardiorespiratory Responses to Exercise in Hypobaric versus Normobaric Hypoxia: A Randomized, Single-Blind, Crossover Study.
Med Sci Sports Exerc
October 2024
Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, ITALY.
Purpose: There is controversy whether there are meaningful physiological differences between hypobaric (HH) and normobaric hypoxia (NH). This study aimed to compare the cardiorespiratory responses to acute HH and NH under strictly controlled conditions. We hypothesized no differences at rest and during submaximal exercise, whereas during maximal exercise, a higher maximal ventilation (V̇Emax), peripheral oxygen saturation (SpO2) and maximal oxygen consumption (V̇O2max) in HH than in NH.
View Article and Find Full Text PDFOxidative Stress Reaction to Hypobaric-Hyperoxic Civilian Flight Conditions.
Biomolecules
April 2024
Hermann Buhl Institute for Hypoxia and Sleep Medicine Research, Department Psychology and Sport Science, University Innsbruck, 6020 Innsbruck, Austria.
Background: In military flight operations, during flights, fighter pilots constantly work under hyperoxic breathing conditions with supplemental oxygen in varying hypobaric environments. These conditions are suspected to cause oxidative stress to neuronal organ tissues. For civilian flight operations, the Federal Aviation Administration (FAA) also recommends supplemental oxygen for flying under hypobaric conditions equivalent to higher than 3048 m altitude, and has made it mandatory for conditions equivalent to more than 3657 m altitude.
View Article and Find Full Text PDFHypoxia matters: comparison of external and internal training load markers during an 8-week resistance training program in normoxia, normobaric hypoxia and hypobaric hypoxia.
Eur J Appl Physiol
August 2024
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Purpose: To compare external and internal training load markers during resistance training (R) in normoxia (N), intermittent hypobaric hypoxia (HH), and intermittent normobaric hypoxia (NH).
Methods: Thirty-three volunteers were assigned an 8-week R program in either N (690 m, n = 10), HH (2320 m, n = 10), or NH (inspired fraction of oxygen = 15.9%; ~ 2320 m, n = 13).
Effects of periodic breathing on sleep at high altitude: a randomized, placebo-controlled, crossover study using inspiratory CO.
J Physiol
November 2024
Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, Italy.
Hypoxia at high altitude facilitates changes in ventilatory control that can lead to nocturnal periodic breathing (nPB). Here, we introduce a placebo-controlled approach to prevent nPB by increasing inspiratory CO and used it to assess whether nPB contributes to the adverse effects of hypoxia on sleep architecture. In a randomized, single-blinded, crossover design, 12 men underwent two sojourns (three days/nights each, separated by 4 weeks) in hypobaric hypoxia corresponding to 4000 m altitude, with polysomnography during the first and third night of each sojourn.
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