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Effects and mechanism of combination of Platycodon grandiflorum polysaccharides and Platycodon saponins in the treatment of chronic obstructive pulmonary disease rats through the gut-lung axis.
J Ethnopharmacol
December 2024
College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China; MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials, Hefei, 230012, Anhui, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, Anhui, 230012, China. Electronic address:
Ethnopharmacological Relevance: Platycodon grandiflorum (Jacq.) A. DC.
View Article and Find Full Text PDFSaponins Improve Angiogenesis in Coronary Heart Disease Based on the microRNA 200a Methylation Pathway.
Drug Des Devel Ther
December 2024
Department of Cardiology, Guang Anmen Hospital, Beijing, People's Republic of China.
Background: Improving angiogenesis in the ischemic myocardium is a therapeutic strategy for preventing, reducing, and repairing myocardial injury of coronary artery disease (CAD). saponins (PNS) have been widely used in the clinical treatment of cardiovascular diseases, demonstrating excellent efficacy, and can potentially improve angiogenesis in the ischemic myocardium. However, the effects of PNS on angiogenesis and its underlying mechanism of action remain unclear.
View Article and Find Full Text PDFImmunohistochemical Staining Properties of Osteopontin and Ki-67 in Feline Meningiomas.
Animals (Basel)
November 2024
VetCore Facility for Research, University of Veterinary Medicine, 1210 Veterinaerplatz 1, 1210 Vienna, Austria.
The high recurrence rate of feline meningioma despite the generally benign histomorphology warrants additional markers of clinical aggressiveness. The Ki-67 index is commonly used as prognostic marker for meningioma recurrence in people. Osteopontin (OPN) is a protein involved in tumor progression and may be a potential malignancy marker.
View Article and Find Full Text PDFArticle Synopsis
- A chondroid syringoma is a rare, non-cancerous skin tumor that can have unique characteristics in its tissue makeup, sometimes causing confusion during diagnosis.
- This report details a case involving this tumor, with unusual bone formation, located on the right upper eyelid of a 60-year-old woman.
- The patient's tumor showed low levels of cell proliferation (Ki67 index) and after a 36-month follow-up, there was no sign of the tumor returning, highlighting the importance of recognizing this tumor's varied appearances to avoid misdiagnosis.
The Potential Protective Role of Ascorbic Acid Against Testicular Toxicity Induced by Fluoxetine in Male Wistar Rats.
J Exp Pharmacol
November 2024
Department of Human Anatomy, Kampala International University, Bushenyi, Uganda.
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- Fluoxetine (FLX) is a common antidepressant that can negatively affect male fertility by increasing Reactive Oxygen Species (ROS), prompting this study on the protective effects of Vitamin C.
- The study involved treating male Wistar rats with fluoxetine and various doses of Vitamin C over 60 days, measuring their testicular weight, sperm parameters, and oxidative stress markers.
- Results showed that higher doses of Vitamin C improved fertility outcomes, increased antioxidant enzyme levels, and protected testicular structure from FLX damage, indicating its potential as a treatment for drug-induced fertility issues.
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