After ovariectomy and 3 daily injections of progesterone plus one of oestradiol-17 beta, 69% of stromal capillaries of the rat uterus became sheathed with pericytes. On Day 5 of pregnancy the value was 74% but at other times (Days 4 and 6) and with progesterone-only or not treatment less than 15% of capillaries were associated with pericytes. This period of pericyte presence coincides with the time when implantation is possible.
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http://dx.doi.org/10.1530/jrf.0.0630267 | DOI Listing |
Sci Rep
January 2025
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Menopause is a natural biological aging process characterized by the loss of ovarian follicular function and decrease estrogen levels. These hormonal fluctuations are associated with increased iron levels, which ultimately lead to iron accumulation. This study aims to investigate the effects of Deferasirox on iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.
View Article and Find Full Text PDFGland Surg
December 2024
Department of Gynecology, Wenzhou People's Hospital, Wenzhou, China.
Background: Infertility is a special reproductive health defect. For women, congenital uterine malformations, extensive adhesions in the uterine cavity, and hysterectomy are associated with infertility. Uterine transplantation is technically feasible, but its clinical application and development are limited by donor shortages and immune rejection.
View Article and Find Full Text PDFReprod Sci
January 2025
Department of Medical Services and Techniques, Pathology Program, Vocational School of Health Services, Gümüşhane University, Gümüşhane, Turkey.
This study aimed to determine the protective role of boric acid in a pregnant rat model of high fructose corn syrup consumption. Consumption of high fructose corn syrup has been associated with adverse health outcomes in humans and animals. Twenty-eight healthy female Wistar albino rats (250-300 g weight and 16-24 weeks old) were randomly distributed into four equal groups (n = 7): Control, Boric acid (BA), High Fructose Corn Syrup (HFCS), HFCS + BA.
View Article and Find Full Text PDFCurr Mol Pharmacol
January 2025
Área Académica de Medicina del Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, México.
Introduction: This work aimed to evaluate the anti-inflammatory and myorelaxant effect of thymol (TM) and carvacrol (CAR) in the pregnant rat uterus. Both compounds exhibit considerable antimicrobial, antispasmodic, and anti-inflammatory effects and due to these properties, they were studied in this in vitro model of premature birth induced by infection.
Method: All uterine tissues were studied in uterine contraction tests to determine the inhibitory effect of TM, CAR (10, 56, 100, 150, and 230 μM), and nifedipine (a calcium channel antagonist) on phasic and tonic contraction induced by electro- and pharmacomechanical stimuli.
Reprod Sci
January 2025
Department of Physiology, College of Graduate Studies, Midwestern University, Downers Grove, IL, 60515, USA.
The experience of pregnancy affects uterine function well beyond delivery. We previously demonstrated that the response to oxytocin is more robust in the uteri of proven breeder rats. This study investigates the contribution of T-type calcium channels (TTCCs) and L-type calcium channels (LTCCs) to the distinct response of virgin (V) and proven breeder (PB) rat uteri to oxytocin.
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