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Retrospective analysis of the incidence and clinicopathological findings associated with ammonium urate urolithiasis in dogs with congenital portosystemic shunts: 363 cases (2010-2023).
J Small Anim Pract
January 2025
Southern Counties Veterinary Specialists, Ringwood, UK.
Objectives: To assess the incidence and clinical findings associated with the presence of ammonium urate urolithiasis in dogs with congenital portosystemic shunts.
Materials And Methods: A retrospective review of dogs diagnosed with extrahepatic portosystemic shunts or intrahepatic portosystemic shunts in 15 referral hospitals between 2010 and 2023. Data including signalment, clinical signs, physical examination findings and clinicopathologic test results at the time of the diagnosis were collected, and the presence of ammonium urate urolithiasis was recorded.
Utilizing the Ellik bladder evacuator during cystoscopic retrieval of urocystoliths in 12 dogs.
J Vet Intern Med
December 2024
North Carolina Veterinary Hospital, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Background: Urocystolithiasis is a common problem in dogs; many canine uroliths are resistant to medical dissolution. Novel management options would expand, and in some cases improve, current urolith retrieval strategies.
Hypothesis/objectives: To describe a previously unreported technique by the Ellik bladder evacuator (EE) to assist in minimally invasive, cystoscopic retrieval of canine cystoliths.
Annexin-derived self-assembling peptide nanostructures for alleviation of calcium oxalate -induced renal injury.
Urolithiasis
December 2024
Materials Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, India.
The formation of polycrystalline aggregates in the glomerulus or other components of the urinary system is indisputably the most critical step in the formation of kidney stones and calcium oxalate monohydrate (CaCO·HO) is the most prevalent form. On the other hand, Annexin A1 (ANXA1), a calcium-binding protein, markedly increased on the apical surface of renal cells in CaCO-induced nephrolithiasis. In this regard, we identified the peptide motif responsible for calcium binding and redesigned it into a self-assembling peptide sequence without disturbing its binding selectivity for the CaCO interface.
View Article and Find Full Text PDFOutcomes of scrotal urethrostomy with poliglecaprone 25 in dogs: 67 cases (2011 to 2023).
Can Vet J
December 2024
Garden State Veterinary Specialists, 246 Industrial Way West, Eatontown, New Jersey 07724, USA.
Objective: To determine the complication rate of canine scrotal urethrostomy (SU) performed with poliglecaprone 25 and identify risk factors for complications.
Animals: We studied 67 dogs treated with SU.
Procedure: Medical records of dogs that underwent SU between 2011 and 2023 at Garden State Veterinary Specialists and its satellite hospitals were reviewed.
Medical dissolution of presumptive upper urinary tract struvite uroliths in 6 dogs (2012-2018).
J Vet Intern Med
November 2024
Department of Urology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Minimally invasive treatments for upper urinary tract uroliths (kidney stones) are the standard in humans and this study explores their application in dogs.
- A total of 6 female dogs with various combinations of kidney and ureter stones were treated using dietary changes, antibiotics, and ureteral stenting, achieving significant urolith dissolution over several months.
- The results suggest that medical dissolution can be an effective strategy for treating struvite uroliths in dogs, potentially avoiding the need for more invasive surgical procedures.
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