Using thorotrastosis for a model we showed that corpuscular radiating substances after entering the vascular space are also being accumulated in the RES (radiophages) of the bone marrow. Redistribution of these substances over the years leads first to mobile and later to immobile deposits of radiophages. This results in a reduction of bone marrow mass in the affected areas as well as myelosclerosis and sometimes in the development of so-called embryonic bone formation (a potentially presarcomatous lesion) and later in the formation of aseptic microsequesters of preexisting spongiosa spicules. Reference is also made to the infrequently observed phagocytosis of osteoblasts and osteocytes.
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