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Recovery of Myocardial Functions After Kidney Transplantation in Patients with Heart Failure Due to Uremic Cardiomyopathy.
Turk Kardiyol Dern Ars
January 2025
Department of Cardiology, Istanbul Basaksehir Cam and Sakura City Hospital, Basaksehir, Istanbul, Türkiye.
Objective: Although left ventricular hypertrophy frequently accompanies end-stage renal disease, heart failure (HF) with reduced ejection fraction (EF) is also observed in a subset of patients. In those patients kidney transplantation (KT) is generally avoided due to an increased risk of mortality in addition to the risks associated with HF. This prospective study was designed to follow patients with HF who were being prepared for KT.
View Article and Find Full Text PDFConsciousness disturbance in patients with chronic kidney disease: Rare but potentially treatable complication. Clinical and neuroradiological review.
Behav Brain Res
March 2025
Radiology and Neuroradiology Unit, Department of Imaging, Radiation Therapy and Hematology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli, 1, Rome 00168, Italy.
Article Synopsis
- In patients with chronic kidney disease undergoing dialysis, brain complications like Posterior Reversible Encephalopathy Syndrome and uremic encephalopathy can develop, with their potential reversibility depending on early detection and treatment.
- Neurological symptoms can range widely from mild consciousness disturbances to coma, and imaging plays a crucial role in diagnosing the specific underlying issues.
- Complications linked to dialysis include Dialysis Disequilibrium Syndrome and Osmotic Demyelination Syndrome, each showing unique imaging patterns, but accurate diagnosis often requires a detailed clinical history and lab results due to occasionally overlapping features.
The uremic toxin indoxyl sulfate decreases osteocyte RANKL/OPG and increases Wnt inhibitor RNA expression that is reversed by PTH.
JBMR Plus
January 2025
Department of Medicine, Division of Nephrology and Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Renal osteodystrophy (ROD) leads to increased fractures, potentially due to underlying low bone turnover in chronic kidney disease (CKD). We hypothesized that indoxyl sulfate (IS), a circulating toxin elevated in CKD and a ligand for the aryl hydrocarbon receptor (AhR), may target the osteocytes leading to bone cell uncoupling in ROD. The IDG-SW3 osteocytes were cultured for 14 days (early) and 35 days (mature osteocytes) and incubated with 500 μM of IS after dose finding studies to confirm AhR activation.
View Article and Find Full Text PDFTeaching NeuroImage: Reversible Symmetric Cytotoxic Edema Affecting White Matter in Uremic Encephalopathy.
Neurology
January 2025
From the Departments of Neurology (J.L., Q.F., S.C., L.R.), Radiology (D.S.), and Nephrology (X.Y.), Panzhou People's Hospital, Panzhou City; and Department of Neurology (D.H.), The Affiliated Hospital of Guizhou Medical University, Guiyang City, China.
Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination-Associated Thrombotic Microangiopathy.
Kidney Int Rep
November 2024
Atrium Health Levine Children's Hospital, Charlotte, North Carolina, USA.
Article Synopsis
- A meta-analysis was conducted to investigate the relationship between COVID-19 and two rare conditions: atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP), revealing that aHUS cases were significantly more associated with COVID-19 infection rather than vaccination, while TTP showed the opposite trend.
- The study analyzed data from 118 reports involving 170 patients, finding that most patients with aHUS required kidney replacement therapy and that severe COVID-19 was linked to poor outcomes in TTP patients.
- The results suggest that both COVID-19 infection and vaccination may trigger these conditions, particularly in pediatric patients, emphasizing the need for awareness and potential management
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