It was demonstrated that under certain experimental conditions the P/O ratio of oleate-treated mitochondria in hypotonic media at low pH values is sharply decreased irrespective of high ADP/O values. This is probably due to a drastic fall in the ionic permeability of membranes induced by ADP. The effect observed is due to ADP (ATP) interaction with nucleotide translocase, since atractyloside eliminates the effect of ADP on the ionic permeability. It was demonstrated that nucleotide translocase is immediately involved in regulation of the functioning of the oxidative phosphorylation system of mitochondria.
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