The results of the study on the antimicrobial activity of 12 chlorine-substituted 4-alkyl- and arylphenols against Staphylococcus, Streptococcus, E. coli, Salmonella typhosa, Salmonella typhimurium, Shigella dysenteriae, Proteus, Klebsiella rhinoscleromatis, Candida, Trichophyton gypseum and Microsporum lanosum are presented. It was found that introduction of the alkyl substitute to position 4 of orthochlorphenol increased the activity of the substances against the majority of test microbes. The antimicrobial effect of the substances depended on the length and structure of the alkyl radical. With an increase in the number of the carbon atoms in the alkyl radical from 3 to 7 and in the presence of the cyclic radical C5 - C6 the antimicrobial activity of the substances increased.
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