Unlabelled: To specify pharmacological interferences between droperidol and fentanyl an experimental study was carried out on mice. The analgesic kinetic was studied after the administration of the two drugs in a concentration ratio between 25/1 and 150/1.
Results: Fentanyl is a potent analgesic with a short time effect. It has very good correlations between dose effect and time effect. Droperidol does not have a analgesic effect. The behaviour of the two drugs depends on the way they are administered, either simultaneously or consecutively: simultaneous administration of the two drugs increases the level and duration of analgesia: nalaxone reverses analgesia, a fentanyl injection given 5 minutes before a droperidol injection produces the same analgesia as fentanyl alone, a droperidol injection given 5 minutes before a fentanyl injection induces a level of analgesia lower than fentanyl alone. Droperidol appears to reverse the fentanyl analgesia.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Lumbar Erector Spinae Plane Block Provides Effective Postoperative Analgesia in Hip Fracture Surgery.
J Coll Physicians Surg Pak
January 2025
Department of Orthopaedics and Traumatology, Faculty of Medicine, Sakarya University, Sakarya, Turkiye.
Objective: To compare the postoperative analgesic effectiveness of ultrasound-guided lumbar erector spinae plane (LESP) block with lumbar plexus block (LPB) in patients operated for proximal femur fractures.
Study Design: A randomised controlled trial. Place and Duration of the Study: Sakarya Training and Research Hospital Operation Theatre, Sakarya, Turkiye, between January and June 2023.
Extraction and quantitation of fentanyl in exhaled breath condensate using a magnetic dispersive solid phase based on graphene oxide and covalent organic framework composite and LC-MS/MS analysis.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center of New Material and Green Chemistry, Khazar University, 41 Mehseti Street, Baku AZ1096, Azerbaijan. Electronic address:
Free fentanyl is responsible for its pharmacological effects, but its total concentration is typically determined for therapeutic drug monitoring purposes. Determination of fentanyl concentration can help reduce the prescribed doses, leading to fewer side effects and increased effectiveness. Therefore, predicting free drug concentration in pharmaceutical research is crucial.
View Article and Find Full Text PDFExpanded Naloxone Distribution by Opioid Overdose Prevention Programs to High-Need Populations and Neighborhoods in New York City.
J Urban Health
January 2025
Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA.
From 2014 to 2017, the drug overdose death rate per 100,000 in New York City (NYC) increased by 81%, with 57% of overdoses in 2017 involving the opioid fentanyl. In response, overdose education and naloxone dispensing (OEND) efforts were expanded in NYC, informed by neighborhood-level and population-level opioid overdose fatality rates. We describe the demographic and geographical distribution of naloxone by NYC opioid overdose prevention programs (OOPPs; the primary distributor of naloxone to laypersons in NYC) as OEND was expanded in NYC.
View Article and Find Full Text PDFIntroduction: Since late 2019, SARS-CoV-2 has infected over 767 million people worldwide with over one million deaths in the United States alone. One risk factor identified for possible worse outcomes from the virus is medication-induced immune suppression. Some opioids have been associated with immunomodulatory effects.
View Article and Find Full Text PDFExparel and Outpatient Alveolar Bone Grafting: A Feasibility Study.
Cleft Palate Craniofac J
January 2025
Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, USA.
Objectives: To examine the feasibility of outpatient alveolar bone grafting (ABG) using Exparel (bupivacaine liposome injectable suspension) for donor site analgesia.
Design: Retrospective, observational study.
Setting: Single institution, 39-month retrospective review.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!