Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ajcp/76.2.243a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran.
Asian J Transfus Sci
December 2022
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Background: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization.
View Article and Find Full Text PDFHaemolytic disease of the fetus and newborn (HDFN) is a rare condition that causes a baby to develop anaemia while growing inside the woman; or after birth. Left untreated, this may lead to stillbirth or neonatal death. HDFN is caused when the pregnant woman's antibodies cross the placenta, enter the baby's circulation, and attach to proteins called antigens (inherited from the father) on the baby's haemoglobin containing red blood cells, and cause them to break apart, causing fetal anaemia.
View Article and Find Full Text PDFAssessment of erythrocyte alloimmunization among patients treated at a Brazilian university hospital.
Hematol Transfus Cell Ther
November 2024
Instituto de Ciências Biomédicas (ICBIM), Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brazil. Electronic address:
Article Synopsis
- This study investigates the frequency of alloimmunization among patients at a Brazilian university hospital, focusing on demographic and clinical characteristics of those with positive irregular antibody screenings.
- Findings reveal that women were more likely to be alloimmunized, with common blood groups A and O, and anti-D, anti-E, and anti-Kell antibodies frequently detected.
- The research emphasizes the importance of thorough antibody screening and erythrocyte immunophenotyping to enhance the safety and effectiveness of blood transfusions in clinical settings.
Management of pregnancies with anti-K alloantibodies and the predictive value of anti-K titration testing.
Lancet Haematol
November 2024
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Clinical Pathology, University Health Network, Toronto, ON, Canada.
Anti-KEL1 antigen (also referred to as anti-Kell, or anti-K) alloimmunisation is the second most common cause of severe haemolytic disease of the fetus and newborn, after anti-rhesus D antigen, and can cause substantial fetal morbidity and mortality. Both fetal erythropoietic suppression and haemolysis contribute to anaemia. Typically, once a clinically significant alloantibody is identified during pregnancy, antibody titration is performed as a screening test to predict the risk of anaemia and the need for maternal-fetal medicine referral.
View Article and Find Full Text PDFELP protocol: an original approach for the mitigation of anti-CD38 interference.
Blood Transfus
June 2024
Transfusion Medicine Department, ULSS 8 Berica, Vicenza, Italy.
Article Synopsis
- Transfusion medicine is having trouble due to new therapies like monoclonal antibodies that mess with blood tests, making it hard to match blood types for transfusions.
- A chemical called dithiothreitol can help solve this problem but has downsides like losing some test accuracy and taking more time.
- Researchers tested a new method that uses dithiothreitol but allows for easier tracking and reduces interference from the antibodies, showing promising results after 30 days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!