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Background: Multiple sclerosis (MS) is an autoimmune disorder affecting the central nervous system, with varying clinical manifestations such as optic neuritis, sensory disturbances, and brainstem syndromes. Disease progression is monitored through methods like MRI scans, disability scales, and optical coherence tomography (OCT), which can detect retinal thinning, even in the absence of optic neuritis. MS progression involves neurodegeneration, particularly trans-synaptic degeneration, which extends beyond the initial injury site.

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Open metal sites are crucial in catalysis. We have used a "loose coordination strategy" (LCS) to preorganize open metal sites in gold cluster catalysts. A gold nanocluster with composition of [Au26(3,4-Me2-Ph-form)9(iPr2-imy)3(Me2S)](BF4)2(iPr2-imy = 1,3-Diisopropylimidazolium tetrafluoroborate, 3,4-Me2-Ph-form = N,N'-Di(3,4-dimethyl-phenyl)formamidine) (Au26) has been obtained by one pot synthesis, i.

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This work deals with the design of nanocomposite hydrogenation-dehydration bifunctional catalysts for the one-pot conversion of CO2 to dimethyl ether (DME), focusing on obtaining a high and homogeneous dispersion of a Cu-based CO2 hydrogenation phase into the pores of mesostructured supports. Particularly, three aluminosilicate mesostructured acid catalysts with catalytic activity towards methanol dehydration and featuring different porous structures (Al-MCM-41, Al-SBA-15, Al-SBA-16) were synthesized and used as supports to host a CuO/ZnO/ZrO2 (CZZ) CO2 hydrogenation catalyst for methanol synthesis. The use of a mesostructured support allows to maximize the exposed surface of the CO2 reduction function by nanostructuring it through its confinement within the mesochannels, thus obtaining nanocomposite bifunctional catalysts with an ultra-small hydrogenation nanophase.

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Quantitative measurement of metabolites is essential to understand biological and disease processes. Absolute quantification by spiking heavy isotope-labeled internal standards and analyzing on mass spectrometry (MS) platform is a key method to determine the concentration of metabolites in biological samples. However, MS-based absolute quantification is often challenged by the commercial availability and high costs of isotope-labeled internal standards.

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Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Accelerates Wound Healing in a Mouse Hind limb Lymphedema Model.

Adv Wound Care (New Rochelle)

January 2025

Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Drugs regulating hypoxia-inducible factor (HIF)-1α have not been investigated for wound healing in lymphedema. Therefore, we examined the effects of drug modulation of HIF-1α activity for wound healing in our previously developed mouse model of nonirradiated hind limb lymphedema. Mouse hind limb lymphedema models ( = 17) and a sham group ( = 6) were created using 8- to 10-week-old male C57BL/6N mice.

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