The state of the neuromediator systems in the formation of a psychosomatic development was studied in 66 patients with different stages of the hypertensive disease. It was demonstrated that the phases of the psychoorganic syndrome frequently correlated with the stages of hypertensive disease and with the qualitative and quantitative transformation of neuromediators in the peripheral blood and that the reactions of the neuromediator systems to dosaged stress may be used to evaluate the stage of the psychoorganic syndrome.
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