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Quantifying cognitive potential relies on psychometric measures that do not directly reflect cortical activity. While the relationship between cognitive ability and resting state EEG signal dynamics has been extensively studied in children with below-average cognitive performances, there remains a paucity of research focusing on individuals with normal to above-average cognitive functioning. This study aimed to elucidate the resting EEG dynamics in children aged four to 12 years across normal to above-average cognitive potential.
View Article and Find Full Text PDFLongitudinal follow-up of metformin treatment in Fragile X Syndrome.
Front Psychol
June 2024
MIND Institute, University of California Davis Health System, Sacramento, CA, United States.
Introduction: Metformin has been used as a targeted treatment to potentially improve cognition and slow the typical IQ decline that occurs during development among individuals with fragile X syndrome (FXS). In this follow-up study, we are following the trajectory of IQ and adaptive behavior changes over 1 to 3 years in individuals with FXS who are clinically treated with metformin in an open label trial.
Method: Individuals with FXS ages 6 to 25 years (mean 13.
Cumulative Dosage of Intrathecal Chemotherapy Agents Predicts White Matter Integrity in Long-Term Survivors of Acute Lymphoblastic Leukemia: A PETALE Study.
Cancers (Basel)
March 2024
Sainte-Justine University Health Center (SJUHC), Montreal, QC H3T 1C5, Canada.
Acute lymphoblastic leukemia (ALL) stands as the most prevalent form of pediatric cancer in North America, with a current five-year survival rate of 85%. While more children achieved ALL remission and transition into adulthood, the prevalence of long-term treatment-related effects, especially neurocognitive sequelae, remains significant. This study pursues two objectives.
View Article and Find Full Text PDFAssociations between Prepartum and Postpartum Maternal Symptoms of Depression, Anxiety and Stress Related to COVID-19 Pandemic and Childhood Sensory Avoidance: Results from Conception Study.
Children (Basel)
March 2024
Department of Psychology, University of Montreal, Marie-Victorin Building, 90 Vincent-D'Indy Avenue, Montreal, QC H2V 2S9, Canada.
Background: Prepartum and postpartum maternal symptoms of stress, anxiety and depression are likely to influence the child's sensory processing through hormonal alterations and an influence on mother-child interactions.
Objective: We investigated the associations between maternal prepartum and postpartum symptoms of depression, anxiety and stress related to the COVID-19 pandemic and childhood sensory avoidance at 18 months.
Methods: Longitudinal data from 409 participants followed during the COVID-19 pandemic were used.
Using rare genetic mutations to revisit structural brain asymmetry.
Nat Commun
March 2024
Mila - Québec Artificial Intelligence Institute, Montréal, QC, Canada.
Asymmetry between the left and right hemisphere is a key feature of brain organization. Hemispheric functional specialization underlies some of the most advanced human-defining cognitive operations, such as articulated language, perspective taking, or rapid detection of facial cues. Yet, genetic investigations into brain asymmetry have mostly relied on common variants, which typically exert small effects on brain-related phenotypes.
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