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http://dx.doi.org/10.1016/0024-3205(81)90094-1 | DOI Listing |
Biophys J
January 2025
Laboratoire Jean Perrin, CNRS, Sorbonne Université, UMR 8237, Paris, France. Electronic address:
In eukaryotic cells, the phospholipid cardiolipin (CL) is a crucial component that influences the function and organization of the mitochondrial inner membrane. In this study, we examined its potential role in passive proton transmembrane flux using unilamellar vesicles composed of natural egg phosphatidylcholine (PC) alone or with the inclusion of 18 or 34 mol % CL. A membrane potential was induced by a potassium gradient, and oxonol VI dye was used to monitor membrane potential dissipation resulting from proton transmembrane efflux.
View Article and Find Full Text PDFJ Plant Physiol
January 2025
Department of Biochemistry & Molecular Biology, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China. Electronic address:
Copper is an essential but potential toxic micro-nutrient in rapeseed. So far, little is known about the mechanism of rapeseed Cu transport and detoxification. Here, we determined the function of Cu transporter, Brassica napus cell number regulator 6 (BnCNR6), in regulating Cu homeostasis.
View Article and Find Full Text PDFCancer Imaging
November 2024
Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: Identifying DNA mismatch repair deficiency (MMRd) is important for prognosis risk stratification in patients with early-stage endometrial cancer (EC), but there is a notable absence of cost-effective and non-invasive preoperative assessment techniques. The study explored the co-reactivity pattern of glucose metabolism and blood perfusion in EC based on hybrid [F]fluorodeoxyglucose ([F]FDG) PET/dynamic contrast enhanced (DCE)-MRI to provide an imaging biomarker for identifying MMRd.
Methods: Patients with a history of postmenopausal bleeding and initially diagnosed with EC on ultrasound were recruited to perform a PET/DCE-MRI scan.
Int Immunopharmacol
January 2025
Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:
Background: Taoren Honghua Decoction (THD) is a traditional Chinese formula known for enhancing blood circulation and demonstrating clinical efficacy in the treatment of cardiovascular and cerebrovascular diseases. However, the primary active components and the underlying mechanisms by which THD exerts its therapeutic effects on atherosclerosis (AS) remain insufficiently characterized.
Objective: This study aims to systematically validate the protective effects of THD on AS and elucidate its potential molecular mechanisms through an integrative approach involving network pharmacology, in vivo, and in vitro experiments.
Mar Pollut Bull
December 2024
Blue Carbon Lab, Deakin Marine Research and Innovation Centre, Deakin University, Burwood campus, 221 Burwood Hwy, VIC 3125, Australia; Centre for Nature Positive Solutions, Biosciences and Food Technology Discipline, School of Science, RMIT University, Melbourne, VIC 3000, Australia.
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