In the past five years cerclage was performed at the Department in 265 pregnant women (1.87% of all births). The outcome of pregnancy is presented in fifteen pregnant women in whom cerclage was performed with the reposition of the prolapsed fetal membranes. In five patients pregnancy was terminated on time, while four of them gave birth to premature infants, and the infants are alive. The total survival rate is 60%. In three of the women pregnancy was effected between the 29th and the 31st weeks, and their newborns died, whereas the remaining three women aborted before the 28th gestation week. The results justify the operation even in such unfavorable cases, as an attempt to maintain pregnancy.
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Int Urogynecol J
January 2025
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Introduction And Hypothesis: The relationship between autophagy and pelvic organ prolapse (POP) remains unknown. The aim of this novel experimental study, utilizing tissue samples derived from women undergoing gynecological surgery, is to investigate the role of autophagy in mitigating collagen degradation in human vaginal fibroblasts induced by oxidative stress, with particular emphasis on its implications in the pathogenesis of POP. Exploring the role of autophagy in protecting against collagen degradation and cellular senescence in human vaginal fibroblasts under oxidative stress may offer new insights into therapeutic strategies for conditions such as POP.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Gynecology, Obstetrics and Neonatology, Division of Gynecology and Obstetrics, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Premature deliveries and preterm newborns are of a special significance to obstetricians. Despite great improvement in neonatal intensive care in the last two decades, prematurity is still the leading cause of neonatal mortality and morbidity. Complications associated with premature deliveries are malpresentation, prolapse of the umbilical cord, entrapment of some parts of the fetal body, as well as severe bruising or bone fractures.
View Article and Find Full Text PDFAnatol J Cardiol
December 2024
Department of Cardiology, Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye.
Background: The precise etiology of hypoplasia of the posterior mitral valve leaflet (PMVL) remains incompletely elucidated; however, it has been hypothesized to stem from genetic mutations occurring during fetal development. Herein, we present the anatomical characteristics of the mitral valve and associated cardiac pathologies in patients with hypoplastic PMVL.
Methods: This single-center retrospective study involved patients who presented between 2015 and 2021 at a tertiary healthcare facility.
Am J Perinatol
January 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
Objective: A single-center randomized trial showed improved latency with use of indomethacin and cefazolin (I/C) during and following exam-indicated cerclage (EIC). The same center recently published a pre/post comparison demonstrating similar results. This research aimed to validate the protocol in a different setting.
View Article and Find Full Text PDFMedicine (Baltimore)
November 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
A typical surgical technique for pregnant women with potentially fatal problems affecting the mother or fetus is an emergency cesarean section (ECS). The decision-to-delivery interval (DDI) for ECS should be within 30 minutes. The objective of this study was to investigate crash ECS indications and effects on maternal and neonatal outcomes.
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