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Protective effect of propranolol on mitochondrial function in the ischaemic heart.
Br J Pharmacol
June 2002
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
1. The present study was aimed to determine whether propranolol improves contractile function of the ischaemic/reperfused heart through protection of the mitochondrial function during ischaemia. 2.
View Article and Find Full Text PDFImpaired endothelium-dependent relaxation of dog coronary arteries after myocardial ischaemia and reperfusion: prevention by amlodipine, propranolol and allopurinol.
Br J Pharmacol
March 1992
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
1. Anaesthetized, open-chest dogs were subjected to 60 min of left circumflex coronary artery occlusion followed by 90 min of reperfusion. Endothelium-dependent and -independent relaxant responses of the isolated coronary arterial rings were then investigated.
View Article and Find Full Text PDFEffects of bradycardic agents on ischaemic myocardium and perfusion in anesthetized dogs.
Eur Heart J
December 1987
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226.
The effects of several new specific bradycardic agents, AQ-A39 and AQ-AH 208, were evaluated in two models of myocardial ischaemia in anesthetized dogs. In the first model, equal bradycardic doses of AQ-AH 208 and propranolol were compared for their effects on coronary collateral blood flow in dogs subjected to an acute coronary artery occlusion. AQ-AH 208 produced a significant (P less than 0.
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