A child with neonatal lupus was evaluated and found to possess serum anti Ro(SSA) antibodies. The cutaneous lesions and anti Ro(SSA) antibodies disappeared during the next 5 mo. The infant's mother was asymptomatic but possessed anti Ro(SSA) and anti La(SSB) antibodies.
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http://dx.doi.org/10.1111/1523-1747.ep12482531 | DOI Listing |
Acta Obstet Gynecol Scand
December 2024
Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Introduction: We investigated the effects of timing of detection and transplacental fluorinated steroid treatment on ventricular heart rate (HR) and age at pacemaker implantation in fetal third-degree atrioventricular block (AVB).
Material And Methods: Twenty-five of 31 fetuses diagnosed with Ro/SSA autoantibody-positive AVB II-III at our tertiary fetal cardiology center (2000-2020) and AVB III as final feto-neonatal outcome were reviewed.
Results: AVB was detected approximately 5 weeks earlier in pregnancy if followed in a surveillance program compared to cases referred from primary care for bradycardia (20.
Introduction: The aim of the study was to investigate the associations between the presence and level of rheumatoid factor (RF) in the blood serum and the clinical and laboratory characteristics of patients with systemic lupus erythematosus (SLE).
Material And Methods: This retrospective tricentric cross-sectional study analyzed a Ukrainian contingent of SLE patients. Medical records of 495 patients were evaluated.
Pacing Clin Electrophysiol
October 2024
Department of Cardiology, Seth GS Medical College and KEM Hospital, Mumbai, India.
We present a case of a neonate who presented with worsening heart failure due to congenital complete atrioventricular (AV) block, secondary to maternal anti Ro/SSA and anti-LA/SSB antibodies. The patient was implanted a temporary pacemaker in view of hemodynamic deterioration and subsequently was weaned off ionotropic support and referred for permanent epicardial pacemaker implantation. We report temporary pacemaker implantation in a neonate with hemodynamic instability as a stabilizing measure and discuss technical challenges for the same.
View Article and Find Full Text PDFMater Sociomed
January 2024
Department of Obstetrics and Gynecology, Democritus University of Thrace, Greece.
Background: Autoimmune diseases encompass a diverse array of disorders that disturb the optimal functioning of the immune system, which is to eliminate the 'foreign or/and dangerous' to mistakenly target the body's own tissues.
Objective: The aim of this research is to evaluate the most effective approach to managing autoimmune diseases within the framework of pregnancy.
Methods: The exact causes and etiologies of these diseases are multifactorial and mostly still unclear.
Mediators Inflamm
February 2024
Department of Clinical Analysis, Center for Health Sciences, Campus Universitário-Trindade, Universidade Federal de Santa Catarina, Florianópolis 88040-970, SC, Brazil.
Traditionally, the treatment of inflammatory conditions has focused on the inhibition of inflammatory mediator production; however, many conditions are refractory to this classical approach. Recently, an alternative has been presented by researchers to solve this problem: The immunomodulation of cells closely related to inflammation. Hence, macrophages, a critical key in both innate and acquired immunity, have been presented as an alternative target for the development of new medicines.
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